{"id":"W4410299677","doi":"10.3390/antibiotics14050495","title":"New Curcumin Analogue (PAC) Inhibits Candida albicans Virulence, Restricts Its Adhesion Potential, and Relieves Oral Epithelial Cell Inflammation and Defense Mechanisms","year":2025,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; King Saud University; Université Laval","keywords":"Curcumin; Candida albicans; Virulence; Inflammation; Adhesion; Microbiology; Chemistry; Cell adhesion; Cell biology; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002647586,0.0002274313,0.0003697178,0.000196127,0.0001840954,0.00006118856,0.00006976293,0.0002348821,0.00002164053],"category_scores_gemma":[0.0002484976,0.000200807,0.00006173448,0.0003814778,0.0001038747,0.000162433,0.00009407507,0.0002393819,0.00001512751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000456185,"about_ca_system_score_gemma":0.0003330607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004142426,"about_ca_topic_score_gemma":0.0004233005,"domain_scores_codex":[0.9985138,0.00007246897,0.0003822683,0.000447781,0.000273344,0.0003103007],"domain_scores_gemma":[0.999163,0.00007729537,0.0001150909,0.0002869306,0.0001406165,0.0002170129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006606574,0.0001220051,0.0445915,0.0006628746,0.00005875704,0.0001294982,0.0003184646,0.000008968364,0.9369646,0.004827903,0.002697581,0.008957248],"study_design_scores_gemma":[0.00267533,0.0006428711,0.2162351,0.0007359989,0.0004564457,0.00002835529,0.0005088231,0.001072233,0.7729668,0.002789072,0.001508288,0.0003807196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988534,0.001060934,0.008058776,0.0007258023,0.0001747447,0.0004202422,0.00003097338,0.00005616293,0.0009383208],"genre_scores_gemma":[0.9905776,0.002142464,0.003417037,0.0002379832,0.00008122535,2.545812e-7,0.00004427362,0.00001755454,0.003481631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1716436,"threshold_uncertainty_score":0.8188671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009472190322143283,"score_gpt":0.2511120904822572,"score_spread":0.241639900160114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}