{"id":"W4410299677","doi":"10.3390/antibiotics14050495","title":"New Curcumin Analogue (PAC) Inhibits Candida albicans Virulence, Restricts Its Adhesion Potential, and Relieves Oral Epithelial Cell Inflammation and Defense Mechanisms","year":2025,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; King Saud University; Université Laval","keywords":"Curcumin; Candida albicans; Virulence; Inflammation; Adhesion; Microbiology; Chemistry; Cell adhesion; Cell biology; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006778234,0.0003662177,0.0002676754,0.0003078149,0.0001119173,0.0001605118,0.0001988662,0.0002494986,0.001877064],"category_scores_gemma":[0.00009383525,0.00009695948,0.0002337943,0.00009612166,0.0001403272,0.0001840374,0.0001498414,0.0004400728,0.0003893759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576625,"about_ca_system_score_gemma":0.0002024286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003944308,"about_ca_topic_score_gemma":0.001112411,"domain_scores_codex":[0.9999449,0.000008943307,0.00000471415,0.00001293017,0.00001603042,0.00001247658],"domain_scores_gemma":[0.9999536,0.000008398729,0.00001249115,0.00000502863,0.00001000304,0.00001039913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003310398,0.0001059595,0.0001610028,0.0006276016,0.00001724888,0.0001429021,0.00001289969,0.0001128857,0.9842907,0.00007194654,0.0003379948,0.01378774],"study_design_scores_gemma":[0.0001506708,0.00298183,0.006731842,0.0001117742,0.0001145857,0.001285624,0.00004405779,0.0007975504,0.9572217,0.00009131702,0.0304413,0.00002773004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9221996,0.06088518,0.006464229,0.0007011843,0.000247885,0.0002329717,0.0009380759,0.0003737537,0.007957058],"genre_scores_gemma":[0.9724166,0.01719305,0.004769455,0.0002231867,0.00005720108,0.0001028341,0.0006774549,0.00003517314,0.004525107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877064,"threshold_uncertainty_score":0.006279409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009472190322143283,"score_gpt":0.2511120904822572,"score_spread":0.241639900160114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}