{"id":"W4410302993","doi":"10.1016/j.jacc.2025.04.005","title":"Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition","year":2025,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia; Providence Health Care","funders":"National Heart, Lung, and Blood Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Medicine; Familial hypercholesterolemia; Limiting; Internal medicine; Pediatrics; Cardiology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001364586,0.0003600158,0.0003846537,0.0005297745,0.0005022438,0.0004337026,0.0002144976,0.0009994145,0.001685997],"category_scores_gemma":[0.001154211,0.0001078081,0.0001725533,0.0003342467,0.0003291245,0.0002891126,0.0002220949,0.0005023726,0.0006434418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001446829,"about_ca_system_score_gemma":0.0002504283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007146475,"about_ca_topic_score_gemma":0.0007350771,"domain_scores_codex":[0.9998301,0.00003347848,0.00002019437,0.00002455939,0.00004753036,0.00004411412],"domain_scores_gemma":[0.9995844,0.0001331265,0.0001020025,0.00002083351,0.00004185582,0.0001178514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0005884501,0.0001915586,0.4440762,0.0001867734,0.0001330269,0.4687746,0.0004203575,0.0001471682,0.02242152,0.002305646,0.0108752,0.0498794],"study_design_scores_gemma":[0.0000220997,0.0003824614,0.3696173,0.0001340723,0.000136152,0.6159977,0.0007090633,0.0004107081,0.002189209,0.002128792,0.008236087,0.00003627298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599916,0.00863105,0.002478414,0.004743839,0.0003317083,0.00002586622,0.0004520061,0.0002201705,0.02312518],"genre_scores_gemma":[0.9974492,0.0009943936,0.0002571929,0.0002902954,0.0001843118,0.000003057362,0.0001303636,0.000007965188,0.0006832536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685997,"threshold_uncertainty_score":0.005640268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139066801589844,"score_gpt":0.2792092176587585,"score_spread":0.2678185496428601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}