{"id":"W4410309233","doi":"10.1038/s42255-025-01290-1","title":"Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"United European Gastroenterology; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Christian-Albrechts-Universität zu Kiel; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Nicotinamide; Placebo; Dysbiosis; Medicine; Microbiome; Coronavirus disease 2019 (COVID-19); Internal medicine; Population; Gut flora; Pharmacology; Physiology; Biology; Disease; Immunology; Bioinformatics; Biochemistry; Pathology; Infectious disease (medical specialty); Environmental health; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003636327,0.0003153046,0.0004676357,0.0003323893,0.0001740088,0.0001039026,0.0002836939,0.0006847493,0.00002123137],"category_scores_gemma":[0.0002922009,0.0003005591,0.0001070839,0.0004681639,0.00006731236,0.00001225689,0.0002660758,0.0005213031,0.000008585874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002841528,"about_ca_system_score_gemma":0.0004339435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000231164,"about_ca_topic_score_gemma":0.0004495604,"domain_scores_codex":[0.9981256,0.0001652898,0.0003664299,0.0007386286,0.00009879064,0.0005052458],"domain_scores_gemma":[0.999168,0.00001999947,0.00008096992,0.0003796102,0.0001249163,0.0002265282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004185282,0.00006758664,0.0006664333,0.00006374926,0.0000809069,0.000006197995,0.00007190013,0.0003930202,0.9849479,0.0008002294,0.01094804,0.001535568],"study_design_scores_gemma":[0.003646406,0.00007443829,0.1228993,0.00004945038,0.0001480092,0.00004411496,0.00006708451,0.0001200836,0.4151673,0.001600879,0.4554674,0.0007155799],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561569,0.03818117,0.000487359,0.003376412,0.0009661322,0.0004691818,0.000103141,0.00002551219,0.0002341857],"genre_scores_gemma":[0.9766538,0.003155833,0.002232328,0.01564612,0.0003607025,0.00002570013,0.0001917383,0.00003047232,0.001703266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5697805,"threshold_uncertainty_score":0.9999446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006425290732883995,"score_gpt":0.2868276270609801,"score_spread":0.2804023363280961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}