{"id":"W4410309233","doi":"10.1038/s42255-025-01290-1","title":"Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19","year":2025,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"United European Gastroenterology; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Christian-Albrechts-Universität zu Kiel; Deutsches Zentrum für Herz-Kreislaufforschung","keywords":"Nicotinamide; Placebo; Dysbiosis; Medicine; Microbiome; Coronavirus disease 2019 (COVID-19); Internal medicine; Population; Gut flora; Pharmacology; Physiology; Biology; Disease; Immunology; Bioinformatics; Biochemistry; Pathology; Infectious disease (medical specialty); Environmental health; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003476377,0.0002747974,0.0006551635,0.0001072697,0.0001506089,0.0002262397,0.0002611542,0.0003278905,0.001168208],"category_scores_gemma":[0.0005270151,0.0001126079,0.0003473806,0.00008819209,0.0001841624,0.0001519662,0.0002414634,0.0004293293,0.0001140304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068033,"about_ca_system_score_gemma":0.0002183157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009540697,"about_ca_topic_score_gemma":0.002429229,"domain_scores_codex":[0.9998736,0.00004973965,0.00001261496,0.00002045534,0.00001650329,0.00002710587],"domain_scores_gemma":[0.9998356,0.00003028713,0.00004725343,0.00001387421,0.00001513901,0.00005782527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2237177,0.01762921,0.04050331,0.001298841,0.001051579,0.0003105459,0.000192288,0.0007330705,0.5761253,0.0001172546,0.0005710426,0.1377499],"study_design_scores_gemma":[0.02440395,0.4369943,0.4361628,0.0002100513,0.001095345,0.0008315207,0.0003671092,0.003159647,0.09309519,0.0002751021,0.003357058,0.00004792471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998833,0.000773029,0.0001319875,0.00002898758,0.00001115322,0.00004748957,0.00004939062,0.000006729714,0.0001182686],"genre_scores_gemma":[0.9987012,0.0004101719,0.0003623541,0.00005286996,0.000009925609,0.00003871363,0.0001354768,0.000002742032,0.0002864151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168208,"threshold_uncertainty_score":0.003908098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006425290732883995,"score_gpt":0.2868276270609801,"score_spread":0.2804023363280961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}