{"id":"W4410313621","doi":"10.1158/2767-9764.crc-24-0565","title":"First-in-Human Study to Evaluate the Safety and Efficacy of Anti-GDF15 Antibody AZD8853 in Patients with Advanced/Metastatic Solid Tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"Eisai; AstraZeneca","keywords":"Antibody; Medicine; Oncology; Solid tumor; Internal medicine; Expanded access; Cancer research; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002590902,0.001613809,0.002270832,0.0002896125,0.0004924001,0.0008919457,0.0007276336,0.001149599,0.003655493],"category_scores_gemma":[0.001067561,0.0005889875,0.001263418,0.0003406051,0.00113088,0.000987558,0.0003227037,0.003302901,0.00105137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001359233,"about_ca_system_score_gemma":0.001570482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006809163,"about_ca_topic_score_gemma":0.001661918,"domain_scores_codex":[0.9992309,0.000400324,0.00004261063,0.0001158014,0.00007502257,0.0001353171],"domain_scores_gemma":[0.9986821,0.0001817664,0.0003310404,0.0001626462,0.00008776055,0.0005546675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6006265,0.1183286,0.02585282,0.001190508,0.002234485,0.0007290553,0.0004214213,0.002500118,0.1192871,0.0003189728,0.005050735,0.1234597],"study_design_scores_gemma":[0.1659367,0.80314,0.01561416,0.00003078569,0.0004365099,0.0006151786,0.0000470518,0.0008770693,0.00933184,0.0001042293,0.003842502,0.00002396721],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911608,0.002755354,0.0009939601,0.0003115788,0.0001203689,0.001821514,0.001140653,0.00009635872,0.001599446],"genre_scores_gemma":[0.9908343,0.001136992,0.001663675,0.0009181029,0.0001971351,0.001187475,0.001928621,0.00003405232,0.002099696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003655493,"threshold_uncertainty_score":0.01370215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05366742063695047,"score_gpt":0.4721786503340532,"score_spread":0.4185112296971027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}