{"id":"W4410317353","doi":"10.3390/ijms26104660","title":"Computational Search for Inhibitors of SOD1 Mutant Infectivity as Potential Therapeutics for ALS Disease","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Mutant; Chemistry; Docking (animal); Dimer; Superoxide dismutase; Wild type; Biochemistry; Point mutation; Biophysics; Cell biology; Biology; Gene; Disease; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003028307,0.001101576,0.001785455,0.000851044,0.0004374608,0.0009468276,0.001059968,0.001103651,0.002771261],"category_scores_gemma":[0.0006841795,0.0004861203,0.001026741,0.0005661149,0.0002971525,0.0004988441,0.0004369419,0.0006050584,0.0002818835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000685379,"about_ca_system_score_gemma":0.00136138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004191025,"about_ca_topic_score_gemma":0.00464773,"domain_scores_codex":[0.9999272,0.00002303772,0.000003666615,0.00001165825,0.00001594392,0.00001842007],"domain_scores_gemma":[0.9997845,0.0001251941,0.00003188544,0.000007159183,0.00002609462,0.00002506189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002613075,0.0001699855,0.001153656,0.0001989894,0.0001531495,0.0001800875,0.00001344654,0.9874816,0.001668266,0.002820768,0.001042802,0.004855923],"study_design_scores_gemma":[0.0001143146,0.000174455,0.0001573567,0.00001691041,0.00008511935,0.00002415047,0.00002188267,0.9968189,0.0005380478,0.001164302,0.0008783377,0.000006226292],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8916583,0.0111213,0.06038827,0.002266958,0.0002720671,0.0003239163,0.001960214,0.001115166,0.03089367],"genre_scores_gemma":[0.9649204,0.002597848,0.02676669,0.0004764365,0.00005637451,0.0004517824,0.001493599,0.00006731413,0.00316963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004191025,"threshold_uncertainty_score":0.009270787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311433387252876,"score_gpt":0.3959603579391908,"score_spread":0.3648170192139032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}