{"id":"W4410318640","doi":"10.2196/preprints.70953","title":"Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial (Preprint)","year":2025,"lang":"en","type":"preprint","venue":"","topic":"Neurological Disorders and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Clinical trial; Stroke (engine); Ischemic stroke; Medical prescription; Randomized controlled trial; Clinical research; Protocol (science); Clinical efficacy; Pilot trial; Disease; Internal medicine; Ischemia; Alternative medicine; Pharmacology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01286461,0.00326696,0.005288465,0.001020629,0.001959957,0.001409496,0.001767258,0.004527591,0.02809994],"category_scores_gemma":[0.01025866,0.001424288,0.003305731,0.001197594,0.001934442,0.001714669,0.0009437518,0.003404717,0.0051161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001579163,"about_ca_system_score_gemma":0.008497637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007252687,"about_ca_topic_score_gemma":0.001590648,"domain_scores_codex":[0.9929643,0.004216756,0.001010297,0.0005305597,0.0006343693,0.0006437461],"domain_scores_gemma":[0.9938835,0.0009128805,0.001580789,0.001014684,0.00133585,0.001272299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9503404,0.01532963,0.000704665,0.004270851,0.0006813213,0.00009152363,0.000112474,0.0005152284,0.003350921,0.000672607,0.008525476,0.0154049],"study_design_scores_gemma":[0.9440097,0.04203106,0.001802068,0.0004594224,0.0004306307,0.00004036006,0.0000315216,0.000518929,0.0008538458,0.0003697043,0.009409846,0.00004285797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02304894,0.0006250641,0.001668042,0.0005585912,0.0005552738,0.9692737,0.002563845,0.0001736474,0.001532884],"genre_scores_gemma":[0.0197418,0.0004372591,0.004015005,0.0009271736,0.0002701274,0.9723576,0.001173549,0.0000128229,0.001064707],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02809994,"threshold_uncertainty_score":0.09400362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029296173177622,"score_gpt":0.3886115417159577,"score_spread":0.2856819243981955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}