{"id":"W4410325451","doi":"10.1038/s41588-025-02189-z","title":"Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder","year":2025,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; BC Mental Health & Substance Use Services; Health Sciences Centre; Sunnybrook Health Science Centre; McMaster University; BC Children's Hospital; Dalhousie University; University of Toronto; Centre for Addiction and Mental Health; University of British Columbia; Hospital for Sick Children","funders":"FP7 Health; Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIH Clinical Center; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; National Institute of General Medical Sciences; Center for Innovative Medicine; Neuroscience Center Zurich, University of Zurich; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; National Human Genome Research Institute; Department of Psychiatry, Columbia University; Yale University; Feinberg School of Medicine; Instituto Nacional de Medicina Genómica; National Institutes of Health; Ingham Institute for Applied Medical Research; Cumming School of Medicine, University of Calgary; Gentofte Hospital; King's College London; St. Olavs Hospital Universitetssykehuset i Trondheim; Deutsche Forschungsgemeinschaft; Ontario Council on Graduate Studies, Council of Ontario Universities; Assistance publique-Hôpitaux de Paris; Department of Health and Social Care; Novo Nordisk Fonden; Universität zu Köln; Universitat de Barcelona; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; H. Lundbeck A/S; Institut National de la Santé et de la Recherche Médicale; Humboldt-Universität zu Berlin; U.S. Department of Veterans Affairs; Region Hovedstaden; Universitetet i Bergen; Helse Midt-Norge; Vetenskapsrådet; Novo Nordisk; Universitetet i Oslo; Lundbeckfonden; Université Paris-Est Créteil Val-de-Marne; Universiteit Stellenbosch; AFA Försäkring; Koninklijke Nederlandse Akademie van Wetenschappen; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Brown University; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Karolinska Institutet; Department of Psychiatry, Faculty of Medicine, University of British Columbia; National Institute for Health and Care Research; University of Queensland; NIHR Maudsley Biomedical Research Centre; Rijksuniversiteit Groningen; Ministero della Salute; Centro de Investigación Biomédica en Red de Salud Mental; National Research Foundation; South African Medical Research Council; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Center for PTSD, U.S. Department of Veterans Affairs; Queensland Health; Mathison Centre for Mental Health Research and Education; Stichting Volksbond Rotterdam; Della Martin Foundation; QIMR Berghofer Medical Research Institute; Vanderbilt University Medical Center; European College of Neuropsychopharmacology; Vrije Universiteit Amsterdam; Amsterdam Neuroscience; Aarhus Universitetshospital; Beatrice and Samuel A. Seaver Foundation; Aarhus Universitet; Stockholms Läns Landsting; Norges Forskningsråd; Ministero dell’Istruzione, dell’Università e della Ricerca; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Instituto de Salud Carlos III; Università degli Studi di Milano; Fudan University; Göteborgs Universitet; Trond Mohn stiftelse; Hospital for Sick Children; Massachusetts General Hospital; Klarman Family Foundation; Ministerio de Ciencia, Innovación y Universidades; BC Children's Hospital; Helse- og Omsorgsdepartementet; South London and Maudsley NHS Foundation Trust; Office of Research and Development; Universitair Medisch Centrum Groningen; European Regional Development Fund; International OCD Foundation; Universitat Autònoma de Barcelona; Eidgenössische Technische Hochschule Zürich; European Social Fund; Medical Research Council; Tartu Ülikool; Fundació la Marató de TV3; Johns Hopkins University; Northwestern University; European Commission; Helsingin Yliopisto; Universität Zürich; University of Cape Town; Georgia Clinical and Translational Science Alliance; School of Medicine, Indiana University; University of New South Wales; University of North Carolina at Chapel Hill; Wayne State University; Universitätsspital Zürich; Vanderbilt University","keywords":"Genome-wide association study; Biology; Genetics; Genetic architecture; Heritability; Genetic association; Single-nucleotide polymorphism; Gene; Phenotype; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006155437,0.0007498304,0.001654278,0.001926386,0.0001204447,0.000599407,0.000742585,0.0006314423,0.002489126],"category_scores_gemma":[0.0006966312,0.0002222067,0.0008830648,0.002229022,0.000259401,0.0003137774,0.0004651736,0.0005823896,0.0006016091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003652131,"about_ca_system_score_gemma":0.000847122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001837741,"about_ca_topic_score_gemma":0.003040989,"domain_scores_codex":[0.9998236,0.00003746639,0.00003334288,0.00004071409,0.00004938791,0.00001548949],"domain_scores_gemma":[0.9996746,0.0001808113,0.00005884802,0.000007657766,0.00005504492,0.00002305753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0003140658,0.00004302917,0.002973107,0.03648681,0.0018508,0.0003783053,0.00005327438,0.0002789792,0.001199899,0.0008125615,0.0140018,0.9416074],"study_design_scores_gemma":[0.0005036084,0.0005398493,0.06278523,0.03308327,0.01302448,0.007984443,0.0003005438,0.0004332773,0.001733736,0.003320426,0.8761668,0.0001243058],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004614103,0.9988907,0.00006296728,0.0001514719,0.00004088857,0.000003388141,0.00005648125,0.000005725643,0.0003270217],"genre_scores_gemma":[0.00370134,0.9956149,0.0001562435,0.0001598934,0.00004886588,0.000006618237,0.0001209132,0.000001613153,0.0001895459],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002489126,"threshold_uncertainty_score":0.008326948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637258384594438,"score_gpt":0.3835201107351003,"score_spread":0.357147526889156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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