{"id":"W4410325544","doi":"10.1161/circresaha.124.325918","title":"FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes","year":2025,"lang":"en","type":"article","venue":"Circulation Research","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Merck Sharp and Dohme; Dutch Cardiovascular Alliance; National Institutes of Health; Diabetes Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; British Heart Foundation; Wellcome Trust","keywords":"CD36; Diabetic cardiomyopathy; Chromatin immunoprecipitation; FOXO1; Internal medicine; Endocrinology; Insulin resistance; Biology; Chemistry; Transcription factor; Insulin; Biochemistry; Medicine; Gene expression; Cardiomyopathy; Promoter; Heart failure; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008576801,0.0001278334,0.0001398358,0.0005887881,0.0001678986,0.00007759792,0.0001486868,0.0002129673,0.0000736155],"category_scores_gemma":[0.0002905081,0.0001417213,0.00007682062,0.0008798291,0.0001205584,0.00003089519,0.00005191652,0.0001956957,0.00003793549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007201156,"about_ca_system_score_gemma":0.0001137881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006749757,"about_ca_topic_score_gemma":0.000169877,"domain_scores_codex":[0.9981995,0.000341141,0.0003058593,0.0004468058,0.0003692808,0.0003374206],"domain_scores_gemma":[0.9991573,0.00004614696,0.0000462118,0.0003774343,0.0003191995,0.00005371504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004583371,0.00006150409,0.3071371,0.00003326018,0.00002981138,2.861995e-7,0.00006600053,0.004544964,0.6765074,0.002074303,0.0004655135,0.009034084],"study_design_scores_gemma":[0.0007141214,0.00004178517,0.9249368,0.0000280256,0.000007652067,3.084052e-7,0.00006881054,0.006384167,0.05441742,0.001503311,0.01176875,0.0001288265],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901904,0.0009270849,0.004616219,0.0005776581,0.0002405065,0.0004816438,0.000005628183,0.00003045006,0.002930411],"genre_scores_gemma":[0.9983261,0.00008198871,0.0001029133,0.0000666987,0.000107591,0.00009498988,0.0003561852,0.00001687509,0.0008466256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6220899,"threshold_uncertainty_score":0.5779225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03264952724594365,"score_gpt":0.3384874893871866,"score_spread":0.3058379621412429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}