{"id":"W4410325544","doi":"10.1161/circresaha.124.325918","title":"FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes","year":2025,"lang":"en","type":"article","venue":"Circulation Research","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Merck Sharp and Dohme; Dutch Cardiovascular Alliance; National Institutes of Health; Diabetes Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; British Heart Foundation; Wellcome Trust","keywords":"CD36; Diabetic cardiomyopathy; Chromatin immunoprecipitation; FOXO1; Internal medicine; Endocrinology; Insulin resistance; Biology; Chemistry; Transcription factor; Insulin; Biochemistry; Medicine; Gene expression; Cardiomyopathy; Promoter; Heart failure; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694111,0.0003530816,0.0002716258,0.0003387057,0.0002771626,0.0003483839,0.0002064223,0.0003529361,0.003542362],"category_scores_gemma":[0.0001096661,0.0001877373,0.0004308509,0.0002730674,0.0004859054,0.0001884203,0.0004257533,0.0007498834,0.0004214951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006508184,"about_ca_system_score_gemma":0.0003536352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008276405,"about_ca_topic_score_gemma":0.001145547,"domain_scores_codex":[0.9998159,0.00001225476,0.00001200341,0.00006998202,0.00003105868,0.00005874856],"domain_scores_gemma":[0.9997923,0.00001434027,0.00007989851,0.00001607582,0.00001855107,0.00007883734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007470818,0.00004025976,0.002256084,0.00008573764,0.00001646384,0.00007406979,0.00003267105,0.0001014327,0.9942613,0.000223086,0.0001617691,0.002000097],"study_design_scores_gemma":[0.0001928444,0.0006437165,0.0849802,0.0000454047,0.0001659143,0.000560942,0.0003127909,0.002369032,0.9009968,0.0005189478,0.009184904,0.0000284731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937927,0.0009626069,0.002208709,0.000246343,0.00008052107,0.00001929758,0.001252215,0.0001858732,0.001251594],"genre_scores_gemma":[0.9928493,0.0006177267,0.001176551,0.0001414993,0.00001707455,0.00004279078,0.0009348978,0.00004524903,0.004174795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003542362,"threshold_uncertainty_score":0.01185042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03264952724594365,"score_gpt":0.3384874893871866,"score_spread":0.3058379621412429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}