{"id":"W4410329684","doi":"10.1111/pcmr.70025","title":"A Dominant Mutation in G<sub>α</sub>s‐Protein Increases Hair Pigmentation","year":2025,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Medical Research Council; Ministerio de Ciencia e Innovación; Wellcome Trust","keywords":"Mutant; GNAS complex locus; Biology; Melanocortin 1 receptor; Melanocyte; Wild type; Mutation; Protein subunit; Molecular biology; Gene; Genetics; Cell biology; Phenotype; Melanoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001331736,0.0001898924,0.0001768444,0.0004166601,0.0001874035,0.00008103189,0.0002412815,0.000166857,0.00003846296],"category_scores_gemma":[0.0001565745,0.0001924276,0.00007007916,0.0004811999,0.00009876839,0.00001458482,0.0001828794,0.0002192273,0.00009506069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732211,"about_ca_system_score_gemma":0.0002165497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002970258,"about_ca_topic_score_gemma":0.0002585322,"domain_scores_codex":[0.997462,0.0005577065,0.0004090594,0.0005667688,0.0005023773,0.0005020654],"domain_scores_gemma":[0.9992154,0.0000756709,0.00008217812,0.0003632931,0.00016771,0.00009572761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003656557,0.0003699865,0.004448121,0.0001073624,0.00002171833,0.00003933227,0.0001040913,0.00004862264,0.9853647,0.0002242419,0.002554345,0.006351806],"study_design_scores_gemma":[0.001996166,0.0003878497,0.01066115,0.00009246393,0.00001032115,0.000004868899,0.000556208,0.0002923156,0.9836947,0.0004198159,0.001706089,0.0001780684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917988,0.000890482,0.00127944,0.0002329601,0.0001256314,0.001066878,0.00001275007,0.00001287719,0.004580187],"genre_scores_gemma":[0.9967548,0.0003538516,0.000351076,0.00008465864,0.0001031826,0.0004955654,0.0005123983,0.00002179982,0.001322719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00621303,"threshold_uncertainty_score":0.7846968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740226620799405,"score_gpt":0.3215874082402818,"score_spread":0.3041851420322877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}