{"id":"W4410332261","doi":"10.1101/2025.05.07.652621","title":"CD33 Epitope Editing Unlocks UM171-Expanded Cord Blood Grafts for AML Immunotherapy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; University of Alberta; Institute for Research in Immunology and Cancer","funders":"","keywords":"Immunotherapy; CD33; Epitope; Medicine; Cord blood; Immunology; Biology; Immune system; Antibody; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478237,0.0002318608,0.000154666,0.0001250932,0.0001113442,0.0003333655,0.0001393045,0.0002154788,0.001157272],"category_scores_gemma":[0.0001158852,0.00008788114,0.0001136097,0.0001171711,0.0001522354,0.00008884306,0.0002251369,0.000402954,0.0004132999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987709,"about_ca_system_score_gemma":0.0001283631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003411692,"about_ca_topic_score_gemma":0.000409201,"domain_scores_codex":[0.9999107,0.00001369136,0.000005375801,0.00002039875,0.00002875373,0.00002113955],"domain_scores_gemma":[0.999938,0.000009186132,0.00002621172,0.000008278743,0.000006665556,0.00001159932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004404231,0.000007836553,0.00009868309,0.00001252106,0.000002203391,0.00003751805,0.000009921857,0.0001886658,0.9974043,0.0001567358,0.00005158318,0.001986042],"study_design_scores_gemma":[0.000003148805,0.00003331758,0.0002821562,0.000001744844,0.000003943627,0.00007315968,0.000004582324,0.0008232557,0.9968001,0.00003013043,0.001943062,0.000001493558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814271,0.0005858968,0.01532668,0.00009011888,0.00004126753,0.00003752023,0.0002673227,0.0002849394,0.00193924],"genre_scores_gemma":[0.9900468,0.00029861,0.006719937,0.00004725183,0.000006938925,0.00001607902,0.000260579,0.000087926,0.002515882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157272,"threshold_uncertainty_score":0.0038715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01189797907732243,"score_gpt":0.2439156458263947,"score_spread":0.2320176667490723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}