{"id":"W4410343021","doi":"10.1093/europace/euaf103","title":"Phenotypic expression of rare progressive cardiac conduction disease variants in the general population","year":2025,"lang":"en","type":"article","venue":"EP Europace","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"St. George's, University of London; Medical Research Council; Barts Health NHS Trust; NIHR Barts Biomedical Research Centre, Queen Mary University of London; Agencia Estatal de Investigación; St George's University Hospitals NHS Foundation Trust; Medical Research Council Canada; European Commission; University College London; British Heart Foundation; National Institute for Health and Care Research; UK Research and Innovation; Queen Mary University of London","keywords":"Medicine; Hazard ratio; Internal medicine; Population; Penetrance; Cardiology; QRS complex; Cohort; Proportional hazards model; Disease; Phenotype; Genetics; Confidence interval; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008479038,0.000259825,0.0003697144,0.0006450382,0.000262834,0.0005915835,0.0002936023,0.0004709658,0.001917976],"category_scores_gemma":[0.003655299,0.0001957796,0.0003529506,0.0006598187,0.0003615633,0.0002968971,0.0004289628,0.0003892352,0.0001453381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196131,"about_ca_system_score_gemma":0.0001069132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002581211,"about_ca_topic_score_gemma":0.002284195,"domain_scores_codex":[0.9992675,0.0001806395,0.00006538186,0.000324244,0.0001018959,0.00006034177],"domain_scores_gemma":[0.9984714,0.0004375687,0.0006783514,0.0002225331,0.00008919674,0.0001010091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000118301,0.0000120975,0.9967136,0.00001174007,0.00009063495,0.0003331338,0.0000664764,0.00009033602,0.0005341363,0.00003664809,0.00006710931,0.001925819],"study_design_scores_gemma":[0.000008012447,0.0001005467,0.9978594,0.000006232381,0.00004961399,0.001411354,0.00006994965,0.0002326611,0.00007332933,0.00009672764,0.00008852396,0.000003679157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990415,0.0002393172,0.0002039884,0.00003382275,0.000002565426,0.00000330122,0.0002887455,0.000005602347,0.000181185],"genre_scores_gemma":[0.9995044,0.0001047594,0.00007654115,0.00001250379,0.000005324675,0.000002960304,0.0002241155,0.000001326255,0.00006803337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581211,"threshold_uncertainty_score":0.006416321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009405174286807049,"score_gpt":0.2815988332235743,"score_spread":0.2721936589367672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}