{"id":"W4410345224","doi":"10.1097/qai.0000000000003694","title":"Investigation of Integrase Inhibitor Resistance Mutations in gp41 in Clinical Samples","year":2025,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; AIDS Vancouver; University of British Columbia","funders":"","keywords":"Elvitegravir; Dolutegravir; Raltegravir; Integrase; Gp41; Integrase inhibitor; Human immunodeficiency virus (HIV); Genetics; Virology; Pharmacology; Medicine; Biology; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007636237,0.000254459,0.0002947519,0.001544706,0.0003573101,0.0005986103,0.0002960562,0.0004424072,0.001517732],"category_scores_gemma":[0.002014229,0.0001406765,0.0001524062,0.0009576438,0.0003382336,0.0002173557,0.0003039006,0.0002980687,0.0003636229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588498,"about_ca_system_score_gemma":0.0002753313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009914591,"about_ca_topic_score_gemma":0.0008746535,"domain_scores_codex":[0.9994258,0.00009999976,0.00007395224,0.0001749926,0.000155513,0.00006977494],"domain_scores_gemma":[0.9990588,0.0002547993,0.0003278165,0.00007553079,0.0001942286,0.00008875733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007237403,0.0001249292,0.9298366,0.0001391939,0.00006499766,0.002604899,0.0003818132,0.0001722359,0.04829463,0.00009228836,0.0004008862,0.01716377],"study_design_scores_gemma":[0.00005453287,0.0009486655,0.9543712,0.00005264318,0.00008756865,0.02040756,0.0005557008,0.0008923748,0.01943044,0.0001268576,0.003063221,0.0000092674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976416,0.0006086351,0.000329646,0.00003316304,0.000004491632,0.00004668802,0.0004597383,0.00001388032,0.0008622524],"genre_scores_gemma":[0.9978923,0.000221965,0.0008677096,0.00005109914,0.000009369819,0.00002773656,0.0007766683,0.000007243391,0.0001458696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544706,"threshold_uncertainty_score":0.005077362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426196351191732,"score_gpt":0.3221639193484352,"score_spread":0.2879019558365179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}