{"id":"W4410348596","doi":"10.1093/jnci/djaf070","title":"Unraveling the role of stromal disruption in aggressive breast cancer etiology and outcomes","year":2025,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Breast Lesions and Carcinomas","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Institutes of Health; Breast Cancer Research Foundation","keywords":"Stromal cell; Breast cancer; Medicine; Oncology; Pathology; Internal medicine; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001027497,0.0003120298,0.000217801,0.0008717348,0.0002019387,0.0009043546,0.0003276155,0.000241561,0.0007155437],"category_scores_gemma":[0.002266741,0.0001732186,0.000248192,0.0007546591,0.0004260787,0.0004713761,0.0006509158,0.000443541,0.000149048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003686051,"about_ca_system_score_gemma":0.0005120392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002598144,"about_ca_topic_score_gemma":0.004104956,"domain_scores_codex":[0.9997237,0.00009061808,0.00002274115,0.00006223547,0.00006005344,0.00004060684],"domain_scores_gemma":[0.998226,0.0003773462,0.0009190941,0.000136252,0.0002090543,0.0001322492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001491846,0.00002818801,0.9703045,0.00008861064,0.0001083045,0.0001083293,0.0001003417,0.001467534,0.004456419,0.0002544018,0.000225883,0.02270835],"study_design_scores_gemma":[0.000007066776,0.0001050094,0.9860302,0.00005983917,0.00009052168,0.0007120775,0.0003506951,0.007925225,0.001588453,0.00143231,0.001687364,0.00001120519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909354,0.00429478,0.00330026,0.0003967137,0.00001021812,0.00001390048,0.0004036008,0.00002705129,0.0006181473],"genre_scores_gemma":[0.9971514,0.001078708,0.001366446,0.00004546031,0.00002637417,0.000005544023,0.0002399872,0.000004943782,0.00008122127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002598144,"threshold_uncertainty_score":0.005433977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01827058893038305,"score_gpt":0.3389768758616336,"score_spread":0.3207062869312505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}