{"id":"W4410349022","doi":"10.1016/j.biomaterials.2025.123404","title":"NanoCRISPR-assisted biomimetic tissue-equivalent patch regenerates the intervertebral disc by inhibiting endothelial-to-mesenchymal transition","year":2025,"lang":"en","type":"article","venue":"Biomaterials","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Foundation for Pharmacy; West China Hospital, Sichuan University; Sichuan Province Science and Technology Support Program; Sichuan University; National Natural Science Foundation of China","keywords":"Materials science; Mesenchymal stem cell; Intervertebral disc; Biomedical engineering; Cell biology; Anatomy; Medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008824559,0.0002477019,0.000171284,0.0001094207,0.0001067178,0.0001549463,0.0002030005,0.0004937697,0.001174586],"category_scores_gemma":[0.0001209077,0.0001132104,0.0001787399,0.00007992131,0.0001489628,0.0002518547,0.0001352168,0.0003659328,0.000261899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394049,"about_ca_system_score_gemma":0.0001770992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000395002,"about_ca_topic_score_gemma":0.0009654242,"domain_scores_codex":[0.9998991,0.000007701397,0.000005879501,0.00002862382,0.00003437114,0.0000242987],"domain_scores_gemma":[0.9999343,0.00001729847,0.00002029648,0.000006719193,0.00001151988,0.000009844949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003720092,0.00001649868,0.00003596981,0.000060482,0.000003273744,0.00005311499,0.00001009574,0.0001352675,0.9975783,0.00009243756,0.00006631477,0.001910944],"study_design_scores_gemma":[0.0000111071,0.0001644534,0.0008169944,0.000004219895,0.00001508429,0.0001578608,0.00001765372,0.001814332,0.9948879,0.00003170057,0.002073388,0.000005246468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810482,0.00230175,0.01258657,0.0001558801,0.000122759,0.00003824603,0.0001171527,0.0001923552,0.003436998],"genre_scores_gemma":[0.9909434,0.0007144442,0.005033978,0.0001001076,0.00001731505,0.00002899318,0.00009639494,0.0000212148,0.003044256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174586,"threshold_uncertainty_score":0.003929436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708516895366232,"score_gpt":0.3177424599872676,"score_spread":0.3006572910336053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}