{"id":"W4410351399","doi":"10.1016/j.cbi.2025.111558","title":"PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models","year":2025,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Silymarin and Mushroom Poisoning","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Applied Basic Research Key Project of Yunnan; National Natural Science Foundation of China","keywords":"Autophagy; Protein phosphatase 2; Apoptosis; Liver injury; Cell biology; Chemistry; Cancer research; Biology; Pharmacology; Phosphorylation; Phosphatase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002919476,0.0009113537,0.0005166695,0.0008576931,0.000359196,0.0003458651,0.0003151225,0.000550771,0.001874601],"category_scores_gemma":[0.0001139241,0.0002871252,0.0006497936,0.000322645,0.0004844774,0.0004890253,0.0001839095,0.001691663,0.0003839738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003640385,"about_ca_system_score_gemma":0.0003675696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007990714,"about_ca_topic_score_gemma":0.001553753,"domain_scores_codex":[0.9998022,0.00003440624,0.00002240215,0.00004110726,0.00004412661,0.00005582979],"domain_scores_gemma":[0.9998716,0.000007058586,0.0000434994,0.00001263811,0.00001772201,0.00004738424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004143151,0.0006672558,0.0004644339,0.0001996863,0.00006249912,0.0001755324,0.00003458366,0.0002017279,0.9896304,0.0002455706,0.0003409368,0.003834266],"study_design_scores_gemma":[0.0002469029,0.002836352,0.005195223,0.00002074032,0.0001357427,0.000261542,0.00007391442,0.001605625,0.9860969,0.0002039053,0.003310816,0.00001232325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830351,0.005610046,0.00548275,0.000718785,0.0004722011,0.0001163428,0.0008426859,0.0005907982,0.003131355],"genre_scores_gemma":[0.9850971,0.003297715,0.003116888,0.0002141449,0.00009930788,0.0001851844,0.0006989762,0.00004631283,0.007244287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874601,"threshold_uncertainty_score":0.006271124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04343526906729295,"score_gpt":0.3131341851569789,"score_spread":0.2696989160896859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}