{"id":"W4410352029","doi":"10.1055/a-2609-9601","title":"Fluorinative Difunctionalization of a Cyclooctene-Fused β-Lactam and Cyclooctene-Fused β-Amino Esters","year":2025,"lang":"en","type":"article","venue":"Synthesis","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Magyar Tudományos Akadémia; European Commission","keywords":"Chemistry; Cyclooctene; Beta-lactam; BETA (programming language); Stereochemistry; Medicinal chemistry; Combinatorial chemistry; Organic chemistry; Antibiotics; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004009209,0.0002815312,0.0004055771,0.0001828573,0.0001745722,0.00001741846,0.0002543514,0.0003717976,0.001179166],"category_scores_gemma":[0.000995949,0.0002886941,0.0001055212,0.0004337027,0.0003559708,0.0001377531,0.000146641,0.0003553316,0.00002228023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343761,"about_ca_system_score_gemma":0.0001443438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003311304,"about_ca_topic_score_gemma":0.000008397499,"domain_scores_codex":[0.9983298,0.000254124,0.0004660433,0.0004378239,0.0001878905,0.0003242865],"domain_scores_gemma":[0.9974352,0.00176492,0.0002032689,0.0002970555,0.0001755583,0.0001239653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007524253,0.0008000582,0.09031653,0.0007372527,0.00118311,0.00002538744,0.000839806,0.0001562018,0.8537706,0.004759599,0.0055865,0.04107251],"study_design_scores_gemma":[0.001396131,0.00004224173,0.03003526,0.00009807439,0.0004920138,0.00001223421,0.0002810752,0.0009967661,0.9404485,0.0008157297,0.025073,0.0003089696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782315,0.0004426118,0.0003326114,0.001635861,0.0008403892,0.0003363906,0.00008649543,0.0001435659,0.0179506],"genre_scores_gemma":[0.9949574,0.0002949614,0.0002922662,0.0004719816,0.0001237073,0.00009758056,0.00001963063,0.00003051896,0.003711945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08667789,"threshold_uncertainty_score":0.9999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04507455913275953,"score_gpt":0.3889272497407408,"score_spread":0.3438526906079812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}