{"id":"W4410352220","doi":"10.1016/j.jaad.2025.05.1385","title":"Efficacy and safety of ruxolitinib cream in children aged 2 to 11 years with atopic dermatitis: Results from TRuE-AD3, a phase 3, randomized double-blind study","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heritage Medical Research Clinic","funders":"Incyte","keywords":"Medicine; Atopic dermatitis; Ruxolitinib; Double blind; Dermatology; Randomized controlled trial; Internal medicine; Alternative medicine; Pathology; Placebo; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967363,0.0007770457,0.001897926,0.0001926782,0.0003507306,0.0005947012,0.0005479849,0.0008961936,0.002405146],"category_scores_gemma":[0.001112522,0.0004075875,0.00155055,0.0002359866,0.0005683667,0.0005302641,0.0002519349,0.001613109,0.0003780754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006894105,"about_ca_system_score_gemma":0.001076672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009054741,"about_ca_topic_score_gemma":0.002736618,"domain_scores_codex":[0.9993305,0.000322681,0.00006620924,0.0001010578,0.00009285425,0.00008669904],"domain_scores_gemma":[0.9990668,0.0002776156,0.0003048424,0.00005590803,0.00007468411,0.0002201512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8462933,0.03094806,0.0215658,0.002416054,0.002574418,0.0004102296,0.0002546665,0.0006149613,0.02026227,0.0001091623,0.001869183,0.07268192],"study_design_scores_gemma":[0.6475934,0.2849225,0.05972398,0.0001264087,0.001509803,0.0005706117,0.00008381822,0.0005000275,0.003063081,0.00006236504,0.001814531,0.00002955438],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937631,0.003785264,0.0002017586,0.0001086316,0.00005066098,0.0009397491,0.0005876118,0.00002777884,0.0005353648],"genre_scores_gemma":[0.9933478,0.00270639,0.001022816,0.0004030178,0.000103711,0.001060342,0.0008235039,0.00001142625,0.0005209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002405146,"threshold_uncertainty_score":0.01040447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449092429133568,"score_gpt":0.3329497472568587,"score_spread":0.318458822965523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}