{"id":"W4410358541","doi":"10.1016/j.ijrobp.2025.05.004","title":"The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Endometrial cancer; Medicine; Oncology; Adjuvant radiotherapy; Adjuvant; Radiation therapy; Internal medicine; Stage (stratigraphy); Retrospective cohort study; Cancer; Gynecology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003834309,0.0002119294,0.000297571,0.0006965701,0.0004039867,0.0004870493,0.0002498761,0.0002749051,0.0008538183],"category_scores_gemma":[0.001142312,0.0002630833,0.0004323421,0.0009874762,0.0003056655,0.0002885101,0.0003629236,0.0002610623,0.000105854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135513,"about_ca_system_score_gemma":0.0003743009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002553915,"about_ca_topic_score_gemma":0.003414572,"domain_scores_codex":[0.9996588,0.00008268892,0.00004517026,0.0001025436,0.00004168072,0.00006912022],"domain_scores_gemma":[0.9992884,0.0001273036,0.000316177,0.0000868957,0.00007845298,0.0001027781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002612682,0.0000198705,0.997627,0.000009542085,0.00006988883,0.00009555805,0.00008128038,0.00004009269,0.0007951965,0.00001176478,0.00002825358,0.0009602985],"study_design_scores_gemma":[0.000008573405,0.000158526,0.9982066,0.000004726207,0.000106601,0.000437979,0.0003230644,0.0001087,0.000295494,0.00001653696,0.0003287624,0.000004375657],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992422,0.0002835031,0.00008558568,0.00001070129,0.000002730232,0.000005567624,0.0001973714,0.000001428457,0.000170992],"genre_scores_gemma":[0.9996145,0.00007229227,0.00004014403,0.000009666272,0.000004139036,0.000004191866,0.0001928752,0.000001340969,0.00006091458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553915,"threshold_uncertainty_score":0.005078137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948861680683844,"score_gpt":0.3772180147108741,"score_spread":0.3477293979040356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}