{"id":"W4410362349","doi":"10.1158/0008-5472.can-24-3990","title":"SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Jewish General Hospital; McGill Genome Centre; McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research","keywords":"SMARCA4; Biology; Cancer research; Ovarian cancer; Polymerase; Cancer; Molecular biology; Chromatin; Chromatin remodeling; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006395416,0.0001767279,0.0002152427,0.0002539456,0.0002521631,0.0000405065,0.0001985198,0.0001681931,0.0001072627],"category_scores_gemma":[0.0003688928,0.0001732968,0.00005206006,0.000721339,0.0001694137,0.000007636971,0.000463986,0.0002900892,0.000003412339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940269,"about_ca_system_score_gemma":0.0008853693,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01830368,"about_ca_topic_score_gemma":0.006649971,"domain_scores_codex":[0.9980896,0.0001636217,0.00027596,0.0006243673,0.0002742045,0.0005722816],"domain_scores_gemma":[0.9990981,0.00006275879,0.00003426665,0.0003815338,0.0002381452,0.0001852161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003709122,0.00007497465,0.0129982,0.000128933,0.00006828368,0.00001804488,0.0001497939,0.0002146798,0.9682482,0.00003546419,0.008809072,0.008883389],"study_design_scores_gemma":[0.001939522,0.0002168213,0.009656008,0.0008627016,0.00002158705,0.000005692767,0.0002390357,0.0004577437,0.9632493,0.0001765543,0.0227759,0.0003991353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822884,0.01475462,0.00003943413,0.00197787,0.0001051769,0.0003480593,0.0001268913,0.00002597064,0.0003335251],"genre_scores_gemma":[0.9935028,0.002983931,0.000112295,0.0009508723,0.0002437433,0.0002977826,0.00004639719,0.00002819882,0.001833995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01396683,"threshold_uncertainty_score":0.9882335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02520908015786484,"score_gpt":0.3666799976417999,"score_spread":0.3414709174839351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}