{"id":"W4410362599","doi":"10.3390/ph18050719","title":"Using UV–Vis Titration to Elucidate Novel Epigallocatechin Gallate (EGCG)-Induced Binding of the c-MYC G-Quadruplex","year":2025,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Gallate; G-quadruplex; Titration; Epigallocatechin gallate; Chemistry; Epicatechin gallate; Pharmacology; Computational biology; Medicine; Biology; Polyphenol; Biochemistry; Nuclear chemistry; DNA; Organic chemistry; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002626906,0.0001675179,0.0001694874,0.00004482028,0.000108123,0.00002451342,0.0003518915,0.0001424097,0.00003865393],"category_scores_gemma":[0.0001286289,0.0001385006,0.0001147397,0.0002716582,0.00006195095,0.000005381728,0.0002608117,0.0001446838,0.000009938129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002993487,"about_ca_system_score_gemma":0.0001046525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000126209,"about_ca_topic_score_gemma":0.000002838801,"domain_scores_codex":[0.9989018,0.00003787824,0.000306016,0.0003250026,0.0001555422,0.0002737557],"domain_scores_gemma":[0.9993263,0.00001709161,0.00008833365,0.0003932331,0.00008146365,0.00009350896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004808696,0.00005945748,0.0009245697,0.00004956849,0.00007007239,4.797264e-7,0.00002285575,0.00008106323,0.9974269,0.0002096173,0.0003096104,0.0007976756],"study_design_scores_gemma":[0.0004441488,0.00001865969,0.0003642209,0.00005668861,0.00006580221,0.000004222309,0.00002398094,0.0009355178,0.9899141,0.00005506401,0.007967391,0.0001502377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909577,0.000099883,0.003904118,0.0007528667,0.0002530413,0.0002435047,0.00002358762,0.00001645117,0.003748801],"genre_scores_gemma":[0.9970563,0.00003011179,0.001312873,0.0009560416,0.00009327344,0.000009526063,0.00001535111,0.00001884133,0.0005076738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00765778,"threshold_uncertainty_score":0.564789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0624195077214968,"score_gpt":0.3793848614440049,"score_spread":0.3169653537225081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}