{"id":"W4410373467","doi":"10.26434/chemrxiv-2025-j90fr","title":"p-Alkoxy Substituted Anisomycins with Potent Anti-Trypanosomiasis Activityand Expanded Modes of Action","year":2025,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Montréal; Centre in Green Chemistry and Catalysis","keywords":"Alkoxy group; Action (physics); Trypanosomiasis; Chemistry; Pharmacology; Medicine; Virology; Physics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001342667,0.0003777961,0.0006734427,0.00008338699,0.0000812071,0.00004510079,0.0003074582,0.0007172351,0.0004058125],"category_scores_gemma":[0.0001681895,0.000278605,0.0002288731,0.0001442651,0.0001308495,0.00006566133,0.0002342487,0.0004481947,0.000005146229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001467211,"about_ca_system_score_gemma":0.000240773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009700464,"about_ca_topic_score_gemma":0.00001800092,"domain_scores_codex":[0.9983026,0.00004480678,0.0004014447,0.000668356,0.0003411238,0.0002416031],"domain_scores_gemma":[0.9984559,0.0001548572,0.0004658978,0.0006377679,0.0002151568,0.00007037885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000251814,0.0003730411,0.006637371,0.0008740603,0.0002805192,0.000003311132,0.00004844595,0.0008341157,0.9782866,0.00003841091,0.00006187225,0.01231042],"study_design_scores_gemma":[0.0005602401,0.00001786115,0.008365848,0.0006323858,0.0002448049,0.000003149996,0.0001424292,0.001337028,0.9878836,0.0003114504,0.0001751229,0.0003260487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902056,0.0002037196,0.000581493,0.0001486839,0.0001005935,0.0002039299,0.00005489678,0.0001252969,0.00837581],"genre_scores_gemma":[0.9981406,0.0004446573,0.000558016,0.00001782702,0.0001572258,0.00008388163,0.000210525,0.00001671861,0.0003705987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01198437,"threshold_uncertainty_score":0.9999666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07353084906759036,"score_gpt":0.3054943126965293,"score_spread":0.2319634636289389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}