{"id":"W4410378349","doi":"10.1111/febs.70131","title":"Discovery and mechanistic characterization of a probiotic‐origin 3β‐ <scp>OH</scp> ‐Δ <sup>5‐6</sup> ‐cholesterol‐5β‐reductase directly converting cholesterol to coprostanol","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Cholesterol; Reductase; Coprostanol; Biochemistry; Biology; Microbiome; Gut flora; Enzyme; Sterol; Mechanism (biology); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006473231,0.0004125518,0.0008603403,0.0005629784,0.000233653,0.000327033,0.0002167577,0.0001876796,0.00001821727],"category_scores_gemma":[0.0005413722,0.0003542188,0.0001705216,0.0005449103,0.0001149856,0.000600479,0.0001510875,0.0006608991,0.00001952269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290841,"about_ca_system_score_gemma":0.000281847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001949665,"about_ca_topic_score_gemma":0.000003713502,"domain_scores_codex":[0.9972486,0.0001646624,0.001001761,0.0005122668,0.0004908646,0.0005817944],"domain_scores_gemma":[0.9982947,0.0001210382,0.0004422796,0.0004095646,0.000315524,0.0004169088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002691449,0.0003683203,0.01372496,0.0006047302,0.0002357555,0.00005515481,0.003149165,0.00002736391,0.9692593,0.0003026011,0.0004471739,0.01155634],"study_design_scores_gemma":[0.01569792,0.001462185,0.387271,0.007525132,0.001741239,0.002939353,0.002178357,0.002012809,0.5370263,0.0005662381,0.04099791,0.0005816481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917591,0.0002751921,0.004834216,0.0009101238,0.0007816124,0.0009596621,0.0001031696,0.0000628644,0.0003140114],"genre_scores_gemma":[0.9927533,0.0001821128,0.0005044073,0.002022586,0.0007591532,0.00003052926,0.00006111772,0.00005719973,0.003629576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.432233,"threshold_uncertainty_score":0.999891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064921143607588,"score_gpt":0.2580985162079513,"score_spread":0.2474493047718754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}