{"id":"W4410378349","doi":"10.1111/febs.70131","title":"Discovery and mechanistic characterization of a probiotic‐origin 3β‐ <scp>OH</scp> ‐Δ <sup>5‐6</sup> ‐cholesterol‐5β‐reductase directly converting cholesterol to coprostanol","year":2025,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Cholesterol; Reductase; Coprostanol; Biochemistry; Biology; Microbiome; Gut flora; Enzyme; Sterol; Mechanism (biology); Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003859617,0.0003348348,0.0003050088,0.0001965089,0.0002009064,0.0005876247,0.0003264554,0.0005304752,0.0008523109],"category_scores_gemma":[0.000390675,0.0001429243,0.0005155423,0.000179763,0.0002409951,0.0003564704,0.0004444568,0.0006252876,0.0004747115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046313,"about_ca_system_score_gemma":0.0005379433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008565721,"about_ca_topic_score_gemma":0.0006847496,"domain_scores_codex":[0.9998466,0.00002409896,0.00001107693,0.0000254758,0.00005459132,0.00003814328],"domain_scores_gemma":[0.9998759,0.00001290292,0.00003086701,0.00001997533,0.00003111688,0.00002925704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002206426,0.00007153244,0.001465325,0.00016134,0.00002779767,0.0004050221,0.00005136864,0.00030189,0.9861101,0.00130539,0.0003458301,0.009533772],"study_design_scores_gemma":[0.0000372359,0.0007399139,0.009126312,0.00004964092,0.00008664098,0.00136534,0.0002134778,0.003284925,0.9554316,0.0008693542,0.02876836,0.00002723395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676861,0.008118891,0.01588595,0.001576808,0.0001623643,0.00009272754,0.001246355,0.0001531041,0.005077882],"genre_scores_gemma":[0.978632,0.003900556,0.01014627,0.0003283079,0.00003779995,0.00003363947,0.003383594,0.00003446392,0.003503335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008565721,"threshold_uncertainty_score":0.002851307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064921143607588,"score_gpt":0.2580985162079513,"score_spread":0.2474493047718754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}