{"id":"W4410382863","doi":"10.1136/thorax-2024-222488","title":"Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial","year":2025,"lang":"en","type":"article","venue":"Thorax","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto; University of British Columbia; McGill University; Université Laval; University of Alberta; Université de Sherbrooke","funders":"Health Research Council of New Zealand; National Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Swedish Orphan Biovitrum; Université Pierre et Marie Curie; Minderoo Foundation; NIHR Imperial Biomedical Research Centre; ZonMw; Sanofi; European Commission; Department of Health and Social Care; National University Health System; Translational Breast Cancer Research Consortium; Wellcome Trust; National Institute for Health and Care Research","keywords":"Medicine; Anakinra; Tocilizumab; Coronavirus disease 2019 (COVID-19); Critically ill; 2019-20 coronavirus outbreak; Intensive care medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Internal medicine; Virology; Outbreak; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00177869,0.0002936721,0.001511057,0.0002821355,0.0002039844,0.00009309347,0.0002966842,0.0001626401,0.0001363816],"category_scores_gemma":[0.1609148,0.0001993967,0.00008303059,0.0005262737,0.0005463159,0.0001901253,0.0005677317,0.0005464043,0.00001219116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005188287,"about_ca_system_score_gemma":0.001915894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007721692,"about_ca_topic_score_gemma":0.0005545158,"domain_scores_codex":[0.997111,0.0002582543,0.0007768852,0.0006477897,0.0006386328,0.0005674011],"domain_scores_gemma":[0.9827375,0.01471775,0.0001313249,0.0005204494,0.001262549,0.000630387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9747358,0.001553428,0.004524008,0.0002621434,0.0004141916,0.0001018503,0.0002380823,0.000005176802,0.000008632718,0.003047189,0.001397531,0.01371195],"study_design_scores_gemma":[0.9781547,0.005929121,0.005112898,0.0003274245,0.0002862015,6.146087e-7,0.0002654659,0.001091756,0.000005258359,0.002745182,0.005857792,0.0002235631],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8603448,0.0009600875,0.005511337,0.05632605,0.0004861213,0.04520822,0.0001827615,0.0002097629,0.03077083],"genre_scores_gemma":[0.9721584,0.000176041,0.001200478,0.02359382,0.00007146397,0.001136668,0.00002039367,0.00002396562,0.001618816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1591361,"threshold_uncertainty_score":0.8461531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07397534580767474,"score_gpt":0.4419939990055278,"score_spread":0.3680186531978531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}