{"id":"W4410395817","doi":"10.1101/2025.05.10.653047","title":"Pleasure in groove is associated with neuromelanin levels in the substantia nigra of younger healthy individuals","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science; Co-creation place formation support program; Precursory Research for Embryonic Science and Technology; Japan Research Foundation for Clinical Pharmacology; Japan Agency for Medical Research and Development; Watanabe Foundation","keywords":"Neuromelanin; Substantia nigra; Pleasure; Neuroscience; Medicine; Psychology; Dopamine; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056624,0.0002417495,0.0003143355,0.0005353058,0.0003109462,0.0003990139,0.0001619741,0.000387596,0.002479902],"category_scores_gemma":[0.001043688,0.00016278,0.0001913307,0.0002792407,0.0002407895,0.0001987284,0.0003492323,0.0003120491,0.0002323886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687112,"about_ca_system_score_gemma":0.00007835162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003642808,"about_ca_topic_score_gemma":0.00722344,"domain_scores_codex":[0.9998842,0.00001258955,0.00001397974,0.0000404204,0.00003101569,0.00001773395],"domain_scores_gemma":[0.9995325,0.00004496557,0.0002356517,0.00002766019,0.0000662247,0.00009295658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007434112,0.0001469971,0.9731897,0.0000563478,0.0001455664,0.0007812273,0.0009389025,0.00002852805,0.01614194,0.00003002211,0.0001712672,0.007626184],"study_design_scores_gemma":[0.00000269027,0.00009185862,0.9992523,0.000002175226,0.00001256139,0.0002651384,0.0001510559,0.00002266581,0.0001249694,0.00001797417,0.00005480538,0.000001853245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995539,0.0001288084,0.00003999425,0.00001567814,0.000002630724,0.000003842805,0.00006524255,0.000001863146,0.0001881204],"genre_scores_gemma":[0.9995426,0.00004514219,0.00005957008,0.0000164492,0.000003261288,0.000003963501,0.00005550456,8.015303e-7,0.0002726889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003642808,"threshold_uncertainty_score":0.008296132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967034697513715,"score_gpt":0.2457660378500877,"score_spread":0.2260956908749505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}