{"id":"W4410401728","doi":"10.1158/0008-5472.can-23-2654","title":"Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; Jewish General Hospital; Montreal Clinical Research Institute; Occupational Cancer Research Centre; University of Toronto; McGill University; Université de Montréal","funders":"Fondation du cancer du sein du Québec; Fonds de Recherche du Québec - Santé; Canada Research Chairs; Canadian Cancer Society; Compute Canada; Canadian Institutes of Health Research; American Cancer Society; Cancer Research Society; National Cancer Institute; Melanoma Research Alliance; Samuel Waxman Cancer Research Foundation; U.S. Department of Defense","keywords":"mTORC1; Dormancy; Breast cancer; Metastasis; Cancer research; Cancer cell; Biology; Cancer; Metastatic breast cancer; PI3K/AKT/mTOR pathway; Signal transduction; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558235,0.0003450135,0.0004045305,0.0002321317,0.0002377348,0.0004937897,0.0003232959,0.0004160286,0.001896678],"category_scores_gemma":[0.0001983292,0.0001701016,0.0003478235,0.000232182,0.0003164466,0.0001760114,0.0003383507,0.0008808643,0.000478935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005794156,"about_ca_system_score_gemma":0.0006103733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574085,"about_ca_topic_score_gemma":0.003250983,"domain_scores_codex":[0.9997904,0.00002230089,0.00002337644,0.00004221404,0.00006426028,0.00005748061],"domain_scores_gemma":[0.9998358,0.00003209845,0.0000593797,0.00001904638,0.00001742203,0.00003620971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009608705,0.00003201541,0.0003915302,0.00003707606,0.000008970329,0.00004882321,0.000008820205,0.0001330713,0.9977154,0.0001138849,0.0001156834,0.001298737],"study_design_scores_gemma":[0.00002267688,0.0003376681,0.005699104,0.000007502227,0.00002755918,0.0003091227,0.00002522263,0.001592908,0.9891846,0.00006555948,0.002720491,0.0000075099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901086,0.001173589,0.00398479,0.0002478069,0.00004283183,0.00006213669,0.001497352,0.0003876231,0.002495324],"genre_scores_gemma":[0.9933469,0.0005025376,0.00287996,0.00009348302,0.00000617771,0.00006960027,0.00114871,0.00004483962,0.001907756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001896678,"threshold_uncertainty_score":0.006345034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07199730393775147,"score_gpt":0.408372764377712,"score_spread":0.3363754604399606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}