{"id":"W4410404287","doi":"10.21203/rs.3.rs-6597157/v1","title":"The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Infectious Encephalopathies and Encephalitis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Université de Montpellier; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; University of Alberta","keywords":"Virus; Inflammatory response; Influenza A virus; Encephalopathy; Virology; Medicine; Immunology; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516239,0.0003362036,0.0003028319,0.0002134166,0.0002359389,0.0006342959,0.0001966492,0.0004795911,0.002691154],"category_scores_gemma":[0.0004784327,0.0001657719,0.0001748372,0.0001409035,0.0002674861,0.0002430097,0.0003173348,0.0007188822,0.00103374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239453,"about_ca_system_score_gemma":0.0002172325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006040046,"about_ca_topic_score_gemma":0.0006365626,"domain_scores_codex":[0.9998398,0.00002343549,0.00000660071,0.00004461779,0.00004439174,0.00004129731],"domain_scores_gemma":[0.9998361,0.0000326726,0.00004411977,0.00001998814,0.00001856523,0.00004856869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006526956,0.00003716544,0.002941636,0.00008793548,0.00003139364,0.0007085815,0.00004711324,0.0007079351,0.9867572,0.002028205,0.001425001,0.004575158],"study_design_scores_gemma":[0.0001820878,0.0003917579,0.1297548,0.0001511018,0.0001695187,0.003990119,0.0005790027,0.02555383,0.8043271,0.008879388,0.0259325,0.00008882072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819833,0.001505201,0.006406401,0.0008039359,0.0004156983,0.00001805669,0.002213727,0.00048695,0.006166742],"genre_scores_gemma":[0.9913031,0.000802819,0.001662748,0.0001631115,0.00006798624,0.00001923881,0.00114835,0.000153503,0.004679157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691154,"threshold_uncertainty_score":0.009002805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879371159296332,"score_gpt":0.369092411768811,"score_spread":0.3402987001758476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}