{"id":"W4410410433","doi":"10.1007/s12311-025-01850-x","title":"Alterations in the Na+/H+ Exchanger NHE6 and Glutamate Transporters may Influence Purkinje Cell Fate in ARSACS","year":2025,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"McGill University","keywords":"Transporter; Purkinje cell; Glutamate receptor; Chemistry; Excitatory amino-acid transporter; Neuroscience; Cell biology; Cerebellum; Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210865,0.0004110299,0.0003855465,0.0005502842,0.0002472583,0.0005754113,0.0003071115,0.0006093366,0.00169169],"category_scores_gemma":[0.0002497794,0.0002235229,0.0005359733,0.0002487765,0.0003872854,0.0004608064,0.0003238815,0.0008032941,0.0004110501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627237,"about_ca_system_score_gemma":0.0001968955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135697,"about_ca_topic_score_gemma":0.002264207,"domain_scores_codex":[0.999731,0.00001736581,0.00004190749,0.00006904398,0.00008272527,0.00005786947],"domain_scores_gemma":[0.9997146,0.00003320848,0.0001092191,0.00003006483,0.00004292286,0.00007003079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002153149,0.0000392011,0.002761662,0.0000583996,0.00002315325,0.000523592,0.00006706981,0.0001052132,0.9946291,0.0001461158,0.00004467148,0.001386592],"study_design_scores_gemma":[0.00003906986,0.0005764877,0.1093256,0.00002866132,0.000120993,0.003209621,0.000374711,0.001061742,0.8811268,0.0003953057,0.003713184,0.00002788062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966774,0.0007626006,0.001221942,0.00005122481,0.00002168703,0.00001397937,0.0004603151,0.00005461085,0.0007361365],"genre_scores_gemma":[0.996538,0.0005354097,0.000537831,0.00004057128,0.00000495041,0.00002503408,0.0004365821,0.00002412394,0.001857476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169169,"threshold_uncertainty_score":0.005659282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008309412223094233,"score_gpt":0.2334977722372359,"score_spread":0.2251883600141416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}