{"id":"W4410410949","doi":"10.1111/acel.70105","title":"<scp>hTERT</scp> Increases <scp>TRF2</scp> to Induce Telomere Compaction and Extend Cell Replicative Lifespan","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Alberta; University of Calgary","funders":"Institute of Aging","keywords":"Telomere; Shelterin; DNA damage; Biology; Senescence; Telomere-binding protein; Telomerase reverse transcriptase; Cell biology; Telomerase; Molecular biology; DNA; Genetics; Transcription factor; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223109,0.0003586479,0.0002735396,0.0002834309,0.000171599,0.0003132725,0.0002433806,0.0004215956,0.0038301],"category_scores_gemma":[0.0001256065,0.0001491842,0.0002698044,0.0002602048,0.0002173827,0.0001676671,0.0001710409,0.0008529075,0.0007878014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005567354,"about_ca_system_score_gemma":0.0002215837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001604917,"about_ca_topic_score_gemma":0.002750802,"domain_scores_codex":[0.999779,0.00002513457,0.00002601399,0.00004402281,0.00008867033,0.00003716147],"domain_scores_gemma":[0.999842,0.00003079267,0.00003506556,0.00002750066,0.00001975859,0.00004485219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006511754,0.00003440534,0.00007160696,0.00002251454,0.000007095251,0.00002967764,0.000004880971,0.00005662449,0.9984439,0.00007988243,0.0001734765,0.001010758],"study_design_scores_gemma":[0.0000105452,0.00009743289,0.001979135,0.000002981913,0.000008920822,0.0001296502,0.000006910637,0.0004350519,0.993222,0.00001850992,0.004086169,0.000002778425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820392,0.002840374,0.004616599,0.0004342546,0.000107588,0.00008294999,0.002969933,0.0005423875,0.006366766],"genre_scores_gemma":[0.9813482,0.0009103599,0.003579764,0.0001883447,0.00002593926,0.00009805088,0.003007036,0.0001177525,0.01072466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0038301,"threshold_uncertainty_score":0.01281297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130915070146431,"score_gpt":0.2748895547712281,"score_spread":0.2617980477565849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}