{"id":"W4410410949","doi":"10.1111/acel.70105","title":"<scp>hTERT</scp> Increases <scp>TRF2</scp> to Induce Telomere Compaction and Extend Cell Replicative Lifespan","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Alberta; University of Calgary","funders":"Institute of Aging","keywords":"Telomere; Shelterin; DNA damage; Biology; Senescence; Telomere-binding protein; Telomerase reverse transcriptase; Cell biology; Telomerase; Molecular biology; DNA; Genetics; Transcription factor; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003650268,0.0004621942,0.0006570094,0.0005405617,0.0003113274,0.0001139516,0.0002668918,0.0001979451,0.00001676226],"category_scores_gemma":[0.0007462639,0.0004417755,0.0001216012,0.0009359586,0.0001596901,0.0002081493,0.000211735,0.0005635946,0.000165931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535574,"about_ca_system_score_gemma":0.000219087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235688,"about_ca_topic_score_gemma":0.00005477919,"domain_scores_codex":[0.9972361,0.0001480824,0.000513252,0.0009933644,0.0003916722,0.0007175569],"domain_scores_gemma":[0.9969708,0.001104512,0.0002172245,0.0008967698,0.0002199104,0.0005908298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008928542,0.001579038,0.3276152,0.001988034,0.0002857657,0.0003455298,0.01331575,0.00003325153,0.4693686,0.0003114846,0.1474074,0.03766056],"study_design_scores_gemma":[0.002331272,0.000471546,0.3543199,0.0008533529,0.0003683151,0.0001031294,0.008691012,0.0002201561,0.4422583,0.0002555747,0.1899249,0.0002025942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608654,0.002571591,0.0003750095,0.0008100998,0.0002917688,0.000741643,0.00002715905,0.0002998615,0.03401741],"genre_scores_gemma":[0.9748806,0.0004666056,0.001040197,0.002991122,0.000313925,0.00004797013,0.00005156735,0.00006025287,0.02014774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04251745,"threshold_uncertainty_score":0.9998034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130915070146431,"score_gpt":0.2748895547712281,"score_spread":0.2617980477565849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}