{"id":"W4410411051","doi":"10.1002/alz.70193","title":"The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Key Scientific Instrument and Equipment Development Projects of China; Servier; H. Lundbeck A/S; Natural Science Foundation of Beijing Municipality; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Cognitive impairment; Cholinesterase; BETA (programming language); Cognition; Medicine; Amyloid beta; Amyloid (mycology); Neuroscience; Psychology; Internal medicine; Disease; Pathology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009498328,0.0003282389,0.0003531577,0.0005163685,0.0003510477,0.0007372603,0.0002199953,0.0003152,0.001080906],"category_scores_gemma":[0.003293632,0.0001449315,0.000668783,0.0005875892,0.0001667351,0.0004511113,0.0004214644,0.0004824028,0.0002051363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004030846,"about_ca_system_score_gemma":0.0005338261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005755115,"about_ca_topic_score_gemma":0.00737543,"domain_scores_codex":[0.9997116,0.00008058995,0.00002889492,0.00005903716,0.00005783425,0.00006216732],"domain_scores_gemma":[0.9982392,0.0004101053,0.0008075795,0.0001041167,0.0001809195,0.0002581983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001177072,0.00006795883,0.9931028,0.00001715511,0.0001431416,0.00004652448,0.00007823415,0.00009167956,0.0001422109,0.0000173115,0.0000416198,0.005074212],"study_design_scores_gemma":[0.00001169824,0.000324016,0.9988647,0.000008503174,0.00008355126,0.0000765742,0.00006992229,0.0003404837,0.00007893609,0.00004417677,0.00009288136,0.000004688998],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988483,0.000569823,0.00005517099,0.00003068907,0.000002807546,0.000005075293,0.0001869496,0.000002565395,0.0002986162],"genre_scores_gemma":[0.9994981,0.0001516429,0.00004779617,0.00001032625,0.000003096972,0.000003508114,0.0001769249,9.802546e-7,0.0001076266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005755115,"threshold_uncertainty_score":0.01144326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861682105843222,"score_gpt":0.3331716846862651,"score_spread":0.3145548636278329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}