{"id":"W4410411720","doi":"10.3390/vaccines13050524","title":"Past, Present, and Future of Viral Vector Vaccine Platforms: A Comprehensive Review","year":2025,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute","keywords":"Immunogenicity; Pandemic; Vector (molecular biology); Viral vector; Virology; Immune system; Biology; Computational biology; Medicine; Coronavirus disease 2019 (COVID-19); Immunology; Infectious disease (medical specialty); Disease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001089827,0.0007841539,0.001022459,0.00246613,0.0002883001,0.001858378,0.0009228244,0.001218724,0.004004523],"category_scores_gemma":[0.001255176,0.0003690724,0.0006988215,0.001779184,0.000463859,0.002756592,0.0007183641,0.001387716,0.001499744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006326344,"about_ca_system_score_gemma":0.00156545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009397814,"about_ca_topic_score_gemma":0.0009989142,"domain_scores_codex":[0.9997246,0.00005418318,0.00004532289,0.0000485675,0.00008917761,0.00003825753],"domain_scores_gemma":[0.9992768,0.0004057907,0.0001026199,0.00001932599,0.0001357607,0.00005974618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001205273,0.0001004009,0.0003593189,0.02549481,0.00008450431,0.0002606021,0.0001318641,0.0007064641,0.004093113,0.006288934,0.0286502,0.9337092],"study_design_scores_gemma":[0.00001095177,0.0002022633,0.0005272055,0.004963839,0.0001262753,0.0009550337,0.00008194839,0.0002242025,0.001052888,0.001954973,0.9898732,0.00002719891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002155594,0.998419,0.0002103415,0.0002985861,0.0002106374,0.000005457384,0.00002290475,0.000009602738,0.0006079122],"genre_scores_gemma":[0.0009349988,0.9979967,0.0002824613,0.0002146024,0.0002058407,0.000007368009,0.00004622888,0.000002529106,0.0003092155],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004004523,"threshold_uncertainty_score":0.01339644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0521268821543681,"score_gpt":0.3902980079281342,"score_spread":0.3381711257737661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}