{"id":"W4410411720","doi":"10.3390/vaccines13050524","title":"Past, Present, and Future of Viral Vector Vaccine Platforms: A Comprehensive Review","year":2025,"lang":"en","type":"review","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute","keywords":"Immunogenicity; Pandemic; Vector (molecular biology); Viral vector; Virology; Immune system; Biology; Computational biology; Medicine; Coronavirus disease 2019 (COVID-19); Immunology; Infectious disease (medical specialty); Disease; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002007373,0.000627121,0.003839721,0.0005020309,0.00006007012,0.00002068201,0.0003546123,0.0003737556,0.00005423091],"category_scores_gemma":[0.00009140614,0.0004026305,0.0006606416,0.0009630148,0.00002795826,0.00008841399,0.0003475138,0.0006380792,0.00003120139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000680727,"about_ca_system_score_gemma":0.0006099491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000040067,"about_ca_topic_score_gemma":0.000003660419,"domain_scores_codex":[0.9974197,0.00008746825,0.001005333,0.0006364519,0.0004240507,0.0004269523],"domain_scores_gemma":[0.9977904,0.000461019,0.0003877341,0.0008741623,0.0004096514,0.00007701487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008475823,0.00007009806,0.0001092512,0.3678652,0.0003771356,0.00004863457,0.00001266869,1.355277e-9,0.000006263419,0.00004761185,0.03267075,0.5987076],"study_design_scores_gemma":[0.000964399,0.0002371147,0.0001214262,0.09747656,0.001911529,0.000168183,0.00001522066,0.000001379886,0.00002471873,0.00002884971,0.8987856,0.0002649964],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007929297,0.9951249,0.000002016711,0.0007623446,0.0002969576,0.002838321,0.00007835467,0.00006567365,0.0007520882],"genre_scores_gemma":[0.000001053895,0.9904448,0.00005882988,0.005969952,0.002948397,0.0002333751,0.00007010531,0.00005778282,0.0002156871],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8661149,"threshold_uncertainty_score":0.9998426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0521268821543681,"score_gpt":0.3902980079281342,"score_spread":0.3381711257737661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}