{"id":"W4410418435","doi":"10.3389/ti.2025.14343","title":"Targeting CD38 in Antibody-Mediated Rejection","year":2025,"lang":"en","type":"review","venue":"Transplant International","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Medicine; Daratumumab; CD38; Immunology; Antibody; Inflammation; Transplantation; Stem cell; Monoclonal antibody; Internal medicine; Cell biology; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002219251,0.0002981187,0.0006775507,0.000732767,0.00006758821,0.00002325519,0.0002916488,0.0005249513,0.002988692],"category_scores_gemma":[0.00008034328,0.0002680503,0.0002904804,0.0002408283,0.00003534273,0.000124921,0.00002486593,0.0008231318,0.001487065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851846,"about_ca_system_score_gemma":0.000145806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00010523,"about_ca_topic_score_gemma":0.00001295797,"domain_scores_codex":[0.9983739,0.0002271227,0.0007379811,0.000371122,0.000053471,0.000236355],"domain_scores_gemma":[0.9992297,0.0003461771,0.000220286,0.0001341064,0.0000600882,0.000009686001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007051138,0.0009792836,0.0003278641,0.01482685,0.002262227,0.0001310839,0.0005569454,0.00003525924,0.01302171,0.002236561,0.04384457,0.9210725],"study_design_scores_gemma":[0.0004564686,0.00002343248,0.00001681046,0.01117348,0.0001368374,0.0001048924,0.00001583167,0.00001056433,0.00006236815,0.000005872691,0.98777,0.0002234408],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008385036,0.9742463,0.0006908337,0.00003934524,0.01533844,0.0003449212,0.0001327885,0.0000965051,0.009102505],"genre_scores_gemma":[0.00012687,0.9622499,0.00001394484,0.00005923834,0.00008053612,0.00005986445,0.016118,0.0000191845,0.02127249],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9439254,"threshold_uncertainty_score":0.9999772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737376178042221,"score_gpt":0.3042712957085693,"score_spread":0.286897533928147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}