{"id":"W4410422177","doi":"10.1016/j.jaad.2025.05.1391","title":"Skin clearance, duration of treatment-free interval, and safety of tapinarof cream 1% once daily: Results from ADORING 3, a 48-week phase 3 open-label extension trial in adults and children down to 2 years of age with atopic dermatitis","year":2025,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Open label; Confidence interval; Duration (music); Interval (graph theory); Extension (predicate logic); Phase (matter); Clinical trial; Randomized controlled trial; Surgery; Internal medicine; Combinatorics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002361187,0.000682592,0.001038862,0.0002406959,0.0002621008,0.0005092189,0.0003709506,0.0006689111,0.002266484],"category_scores_gemma":[0.001573012,0.0002320264,0.001123236,0.000257216,0.0004072632,0.0006066852,0.000200613,0.001584201,0.0003035789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003953505,"about_ca_system_score_gemma":0.0005203427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634648,"about_ca_topic_score_gemma":0.001039618,"domain_scores_codex":[0.9992961,0.0003124931,0.0000664301,0.00009661687,0.0001258267,0.000102511],"domain_scores_gemma":[0.9981331,0.0005351381,0.0006130497,0.0001270566,0.0001249656,0.0004667458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7080075,0.04039624,0.03243304,0.001220868,0.001588977,0.0002414983,0.0004280494,0.00126351,0.03504309,0.0001236952,0.002724689,0.1765288],"study_design_scores_gemma":[0.3194066,0.5531608,0.1174718,0.00007855635,0.0009926173,0.0006722726,0.00008633908,0.001184913,0.005035114,0.0001218633,0.001745031,0.00004418593],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962791,0.001984624,0.0002023402,0.00006058449,0.00001668526,0.0003845304,0.0004872999,0.00002546416,0.0005593758],"genre_scores_gemma":[0.9969919,0.0008697082,0.0004145062,0.0001376524,0.00005902807,0.000306485,0.0008626339,0.00001038522,0.0003476151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361187,"threshold_uncertainty_score":0.01248735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729761670407963,"score_gpt":0.3214463128655334,"score_spread":0.3041486961614537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}