{"id":"W4410426235","doi":"10.1101/2025.05.15.25327709","title":"Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Sherbrooke; Canadian Sleep & Circadian Network","funders":"Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Allergan; National Institutes of Health; Agentura Pro Zdravotnický Výzkum České Republiky; European Commission; Ministerstvo Školství, Mládeže a Tělovýchovy; Parkinson's UK; National Institute for Health and Care Research; Biogen; Celgene; AbbVie; Bristol-Myers Squibb","keywords":"REM sleep behavior disorder; Dementia with Lewy bodies; Dementia; Sleep (system call); Neuroscience; Psychology; Medicine; Audiology; Internal medicine; Polysomnography; Electroencephalography; Computer science; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122723,0.0005145126,0.0003279865,0.0006338653,0.0002827101,0.0005775391,0.0002842728,0.0003532245,0.002453946],"category_scores_gemma":[0.00120029,0.0001576228,0.0002879378,0.000269862,0.0002903255,0.0003156132,0.0004217259,0.0003308298,0.0002749305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440587,"about_ca_system_score_gemma":0.0001534046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005141179,"about_ca_topic_score_gemma":0.006012537,"domain_scores_codex":[0.9999273,0.00001570885,0.00001063505,0.00002466699,0.000009478967,0.00001222309],"domain_scores_gemma":[0.9995494,0.0000817132,0.0002015303,0.0000362086,0.00004530164,0.00008585475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0010836,0.00008215211,0.9921409,0.00003119576,0.00009576658,0.0001775394,0.00007696954,0.0001350234,0.001782009,0.00003574535,0.0002583888,0.004100537],"study_design_scores_gemma":[0.00002539963,0.0001531372,0.9981719,0.00001458766,0.00004097559,0.0003269348,0.0001115956,0.0004731523,0.0003786121,0.0001801427,0.0001199359,0.000003580479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991345,0.000171994,0.00008251403,0.00004098734,0.000005200818,0.000004278096,0.0002518821,0.000006350972,0.0003022893],"genre_scores_gemma":[0.9992668,0.00004630299,0.0001205849,0.00001459667,0.000005262398,0.000002638377,0.0003648487,0.000002069048,0.000176848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005141179,"threshold_uncertainty_score":0.01022249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03146005739644984,"score_gpt":0.2875833029131995,"score_spread":0.2561232455167496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}