{"id":"W4410431487","doi":"10.1073/pnas.2415779122","title":"Mutant <i>IDH1</i> cooperates with <i>NPM1c</i> or <i>FLT3</i> <sup>ITD</sup> to drive distinct myeloid diseases and molecular outcomes","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Innovation and Technology Commission; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Vallee Foundation; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Cancer Research Institute; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; National Institute of Mental Health; WorldQuant Foundation; Starr Cancer Consortium","keywords":"IDH1; Isocitrate dehydrogenase; NPM1; Myeloid leukemia; Mutant; Cancer research; IDH2; Mutation; Myeloid; Biology; Gene; Genetics; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266923,0.0002614793,0.0002724064,0.0001838798,0.0001262495,0.0002731531,0.0001762502,0.0002089765,0.0006220624],"category_scores_gemma":[0.00007750084,0.0001257008,0.0001629308,0.0001237814,0.0002626499,0.0001143688,0.0001866958,0.0005318715,0.0002054204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003664907,"about_ca_system_score_gemma":0.0002291415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007954039,"about_ca_topic_score_gemma":0.00154198,"domain_scores_codex":[0.9998486,0.00001957517,0.00001933988,0.00003281052,0.0000474447,0.0000321845],"domain_scores_gemma":[0.9998977,0.00001365665,0.00003157761,0.00001454564,0.000004969497,0.0000374488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007113032,0.00002537362,0.0002309511,0.000009017078,0.000002925619,0.0000371299,0.000006426429,0.00008389717,0.9988734,0.00007899921,0.0000280476,0.0005527026],"study_design_scores_gemma":[0.00001792668,0.0003322049,0.004645866,0.000002212698,0.00001483398,0.0003878058,0.0000187772,0.000897059,0.9918902,0.00004026768,0.001748102,0.00000466131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978091,0.0002672713,0.0007852092,0.00005888061,0.0000120417,0.00001560646,0.0002682189,0.00004881071,0.0007348493],"genre_scores_gemma":[0.9972452,0.0001761126,0.001133689,0.00003930866,0.000004577214,0.00002072921,0.0003223453,0.00001967692,0.001038348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007954039,"threshold_uncertainty_score":0.002659142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190858789934894,"score_gpt":0.3147441394947954,"score_spread":0.295658260501306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}