{"id":"W4410436385","doi":"10.1016/j.devcel.2025.04.022","title":"Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration","year":2025,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; SickKids Foundation; University Health Network; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute; Brain Tumour Foundation of Canada; Canada Foundation for Innovation; Ontario Institute for Cancer Research; Natural Sciences and Engineering Research Council of Canada; American Brain Tumor Association; Princess Margaret Cancer Foundation; Fondation Brain Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Oligodendrocyte; Glioblastoma; Lineage (genetic); Infiltration (HVAC); Neuroscience; Cancer research; Gene; Genetics; Central nervous system; Myelin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008454595,0.0001877709,0.0001603465,0.00008720008,0.00009187326,0.00002915833,0.0002011062,0.0001217677,0.00001381849],"category_scores_gemma":[0.0000110059,0.0001974736,0.00007543853,0.0001921691,0.0000803968,0.000008421591,0.0001035445,0.00008720392,0.000008401761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003307881,"about_ca_system_score_gemma":0.0001934392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000153038,"about_ca_topic_score_gemma":0.00006077443,"domain_scores_codex":[0.9989403,0.00002834384,0.0003496973,0.0003186496,0.0001357046,0.0002273438],"domain_scores_gemma":[0.99967,0.000007204639,0.00008595361,0.0001281557,0.00005864252,0.00005002916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248533,0.0001829376,0.03536046,0.00008162591,0.00003848658,0.000003393036,0.0002243988,0.0000147741,0.9579157,0.00003198114,0.000253695,0.005767662],"study_design_scores_gemma":[0.0006640772,0.000151407,0.0119978,0.00004448025,0.00001108414,0.000007645975,0.0001803547,0.00005061748,0.9765273,0.000005084446,0.01015855,0.0002015753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886745,0.000152849,0.00168623,0.00001224517,0.0002949262,0.0002272728,0.000006250046,0.0000254131,0.008920323],"genre_scores_gemma":[0.9913074,0.00007256886,0.006918289,0.0001810479,0.00003837373,0.00001894837,0.0001818713,0.000019048,0.001262485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02336266,"threshold_uncertainty_score":0.8052741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007682543518620875,"score_gpt":0.2142988694469704,"score_spread":0.2066163259283495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}