{"id":"W4410436385","doi":"10.1016/j.devcel.2025.04.022","title":"Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration","year":2025,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; SickKids Foundation; University Health Network; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute; Brain Tumour Foundation of Canada; Canada Foundation for Innovation; Ontario Institute for Cancer Research; Natural Sciences and Engineering Research Council of Canada; American Brain Tumor Association; Princess Margaret Cancer Foundation; Fondation Brain Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Oligodendrocyte; Glioblastoma; Lineage (genetic); Infiltration (HVAC); Neuroscience; Cancer research; Gene; Genetics; Central nervous system; Myelin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006611132,0.0001041725,0.0001447348,0.0001537218,0.00008820101,0.000250939,0.00007219407,0.000123185,0.0004833162],"category_scores_gemma":[0.00005916971,0.00006999848,0.00008360973,0.0001157201,0.0001637063,0.00009560864,0.0001296925,0.00022845,0.0001251832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780987,"about_ca_system_score_gemma":0.0001958911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000643831,"about_ca_topic_score_gemma":0.001602039,"domain_scores_codex":[0.9999422,0.000005417407,0.000002782643,0.00001535811,0.00001803596,0.00001630692],"domain_scores_gemma":[0.9999669,0.000003470964,0.00001461587,0.000002923533,0.000003687402,0.000008424423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003626411,0.00000636375,0.001098982,0.0000142722,0.000002400158,0.00004328886,0.0000201593,0.00004957118,0.9972523,0.000120575,0.00001953319,0.001336324],"study_design_scores_gemma":[0.000005787929,0.0001815719,0.06373589,0.00001027777,0.00002216139,0.0004409898,0.000194728,0.00171478,0.9301917,0.000281261,0.003215222,0.000005729505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959182,0.0006429073,0.002343187,0.00003881918,0.000005682408,0.000008607711,0.0003156141,0.00005658914,0.0006703922],"genre_scores_gemma":[0.9974728,0.0005207119,0.0008862796,0.00003129768,0.000002139381,0.00000978797,0.0002195441,0.00000944267,0.0008479669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000643831,"threshold_uncertainty_score":0.001616836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007682543518620875,"score_gpt":0.2142988694469704,"score_spread":0.2066163259283495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}