{"id":"W4410443517","doi":"10.1101/2025.05.14.651875","title":"Inhibition of IL2Rß-dependent STAT5 activity supports T-cell stemness and augments antitumor efficacy of CD8 <sup>+</sup> T cells by preventing T-cell exhaustion","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Centre hospitalier universitaire Sainte-Justine; Parker Institute for Cancer Immunotherapy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cytotoxic T cell; Cancer research; Cell biology; CD8; T cell; STAT5; Chemistry; Cell; Biology; Immunology; Signal transduction; Immune system; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102685,0.0003053265,0.0001600042,0.0001273761,0.00006994663,0.0002494082,0.0001257825,0.0001327668,0.001426548],"category_scores_gemma":[0.00004518731,0.00005752457,0.0001682801,0.00007637766,0.000134096,0.00009456914,0.00009602757,0.0005978716,0.0003566427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390289,"about_ca_system_score_gemma":0.0001763768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003186533,"about_ca_topic_score_gemma":0.0006604298,"domain_scores_codex":[0.9998802,0.00001805344,0.00001539117,0.00001655335,0.00003237117,0.00003733995],"domain_scores_gemma":[0.9999501,0.000007277902,0.00001652989,0.000005038583,0.000004123595,0.00001687163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499774,0.000054231,0.0001045556,0.00003400451,0.000003653382,0.00001212423,0.000005743873,0.00009087035,0.998548,0.00004081277,0.0000525649,0.0009034123],"study_design_scores_gemma":[0.0000281882,0.0007303415,0.001499904,0.000006251301,0.00001134392,0.00005844225,0.00001380175,0.0007481403,0.9954162,0.0000189761,0.001466071,0.000002318235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948729,0.001408895,0.001429525,0.00009402347,0.00004576591,0.00002773051,0.000376274,0.00009671434,0.001648129],"genre_scores_gemma":[0.9967811,0.000452808,0.0009740364,0.0000485368,0.00001450036,0.00002532115,0.0004017452,0.00001116648,0.001290746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001426548,"threshold_uncertainty_score":0.004772305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007891976508719771,"score_gpt":0.2120839007433394,"score_spread":0.2041919242346196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}