{"id":"W4410444332","doi":"10.1038/s41398-025-03389-1","title":"Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; University of California, San Diego; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; Alzheimer's Association","keywords":"Dementia; Cognition; Sleep (system call); Medicine; Sleep quality; Psychology; Clinical psychology; Audiology; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002747518,0.0001325692,0.000176976,0.0002639519,0.0002055214,0.00006406823,0.000137721,0.00009413718,0.00006609682],"category_scores_gemma":[0.00007183868,0.0001380977,0.00005301067,0.0004485678,0.00004480822,0.0001918101,0.00002454384,0.0002470511,0.0000229485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001755695,"about_ca_system_score_gemma":0.00009091423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003692018,"about_ca_topic_score_gemma":0.000281675,"domain_scores_codex":[0.9982359,0.0002242725,0.0004118507,0.0004191916,0.0004565552,0.0002521617],"domain_scores_gemma":[0.9993676,0.0003332588,0.00007103966,0.0001224766,0.00004145587,0.00006415536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001110246,0.0002810509,0.9681485,0.00005296855,0.00003789246,8.691703e-7,0.0002849063,0.00003207232,0.001220788,0.02331709,0.0001812089,0.00633167],"study_design_scores_gemma":[0.002752632,0.00002380882,0.981086,0.00008294689,0.00004338259,6.059279e-7,0.00003850968,0.0006772585,0.002990178,0.01202732,0.0001311823,0.000146175],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789663,0.0001280919,0.001167543,0.01114251,0.0003704802,0.0005052422,0.0001422276,0.00005120987,0.007526417],"genre_scores_gemma":[0.9988888,0.00001427995,0.0003087661,0.0005211944,0.00008530731,0.00004349854,0.00006255676,0.00001124361,0.00006437392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0199225,"threshold_uncertainty_score":0.5631463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03725930809788565,"score_gpt":0.3449476621983967,"score_spread":0.307688354100511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}