{"id":"W4410446296","doi":"10.3390/microorganisms13051140","title":"Increased Expression of AbcA Efflux Pump Accelerated Resistance Development from Tolerance to Resistance Against Oxacillin in Staphylococcus aureus","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Efflux; Mutant; Staphylococcus aureus; Biology; Complementation; Microbiology; Gene knockout; Antibiotic resistance; Wild type; Genetics; Antibiotics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009606805,0.0002497849,0.0002833353,0.0001631939,0.00008064485,0.0002501214,0.0001264465,0.0002247035,0.0006300641],"category_scores_gemma":[0.0001587539,0.0001281577,0.000221705,0.0001057411,0.00014799,0.0001865697,0.0002294527,0.0003869671,0.0001386238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825119,"about_ca_system_score_gemma":0.000168965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005667485,"about_ca_topic_score_gemma":0.0005374011,"domain_scores_codex":[0.9998443,0.0000291968,0.00002485261,0.00002938014,0.00004289132,0.00002932108],"domain_scores_gemma":[0.9998692,0.00001923995,0.00004886351,0.00001498517,0.00001737788,0.00003024941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003040394,0.00001109058,0.0001798071,0.000008771279,0.000001624242,0.00002765656,0.000005055671,0.00001032421,0.9993506,0.00001577407,0.000006162943,0.0003527575],"study_design_scores_gemma":[0.000009503976,0.0004589575,0.01977332,0.000007896893,0.00001727127,0.0005217095,0.00006330183,0.001011684,0.9772568,0.0000431541,0.0008277149,0.000008726996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982916,0.0003121204,0.001044697,0.00005055404,0.00001015479,0.000005934204,0.0000720692,0.00002456159,0.0001883524],"genre_scores_gemma":[0.9977028,0.0002186316,0.001086986,0.00002549542,0.00000348348,0.00001291839,0.000104816,0.00000896936,0.0008358355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006300641,"threshold_uncertainty_score":0.002107739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007321540438950611,"score_gpt":0.2352050368710742,"score_spread":0.2278834964321236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}