{"id":"W4410446296","doi":"10.3390/microorganisms13051140","title":"Increased Expression of AbcA Efflux Pump Accelerated Resistance Development from Tolerance to Resistance Against Oxacillin in Staphylococcus aureus","year":2025,"lang":"en","type":"article","venue":"Microorganisms","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Efflux; Mutant; Staphylococcus aureus; Biology; Complementation; Microbiology; Gene knockout; Antibiotic resistance; Wild type; Genetics; Antibiotics; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002524829,0.0003428656,0.0004462549,0.0001423347,0.0001080934,0.00004826053,0.0006327677,0.0002869176,0.00004283766],"category_scores_gemma":[0.0001754735,0.0003565135,0.00006677951,0.000509442,0.00009914155,0.00001048259,0.0002370523,0.0001549948,0.00001920199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388624,"about_ca_system_score_gemma":0.0003961839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004532217,"about_ca_topic_score_gemma":0.001545189,"domain_scores_codex":[0.9976551,0.0001319455,0.0007599961,0.0008067178,0.0002106314,0.0004356393],"domain_scores_gemma":[0.9986416,0.00004184138,0.0002095053,0.000802941,0.0001977504,0.0001064228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007056286,0.0001192687,0.0143448,0.00008633122,0.00003228139,0.000009477008,0.0002053566,0.00003017054,0.9803085,0.00001766355,0.003942512,0.0001980101],"study_design_scores_gemma":[0.0009403059,0.0000202515,0.08986747,0.0005751342,0.00000692293,5.925199e-8,0.00009668105,0.000001095293,0.8677334,0.00005142346,0.04039866,0.0003086045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993627,0.001187736,0.00287118,0.0001366731,0.0002000521,0.0005138586,0.0001280479,0.00002698104,0.001308539],"genre_scores_gemma":[0.9765149,0.00009323993,0.01983684,0.0005581234,0.00006120632,0.00002803639,0.0002658653,0.00004084657,0.002600954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1125751,"threshold_uncertainty_score":0.9998887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007321540438950611,"score_gpt":0.2352050368710742,"score_spread":0.2278834964321236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}