{"id":"W4410446705","doi":"10.21203/rs.3.rs-6647740/v1","title":"Digitally Immune-Optimised Next-Generation Influenza Vaccine Provides Cross-Clade Protection Against Emerging H5Nx Viruses","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada","funders":"UK Research and Innovation; Bill and Melinda Gates Foundation","keywords":"Clade; Virology; Immune system; Influenza vaccine; Biology; Immunology; Vaccination; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378885,0.0002867578,0.0002644523,0.0001336866,0.0001098341,0.0006000358,0.0002456672,0.0005059796,0.007015375],"category_scores_gemma":[0.0003995232,0.0001292185,0.0002658245,0.00007485301,0.0001587732,0.0005557471,0.0004067293,0.0005552065,0.001504512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254353,"about_ca_system_score_gemma":0.0002366567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000248033,"about_ca_topic_score_gemma":0.0002953733,"domain_scores_codex":[0.9998732,0.00001515381,0.000003737056,0.00003283731,0.0000374088,0.00003770076],"domain_scores_gemma":[0.9999288,0.00001774183,0.00001272255,0.00001111881,0.0000147035,0.00001493804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001583119,0.0003630683,0.00237194,0.0003994005,0.00009294446,0.0001563506,0.00004632596,0.03140322,0.8542733,0.005464366,0.008577211,0.09526862],"study_design_scores_gemma":[0.0003988657,0.002143772,0.00597077,0.00005340615,0.0001445736,0.0004206971,0.0001013228,0.2520626,0.688283,0.006988627,0.04337491,0.00005746821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8335698,0.005892448,0.1092829,0.002753025,0.002547389,0.0002368896,0.002170386,0.002327434,0.04121976],"genre_scores_gemma":[0.9621652,0.0009634427,0.02508147,0.000499898,0.0001584391,0.00006320981,0.001179111,0.00008373812,0.009805583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007015375,"threshold_uncertainty_score":0.02346879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3050009588177925,"score_gpt":0.4906299445073,"score_spread":0.1856289856895075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}