{"id":"W4410453629","doi":"10.1111/bph.70047","title":"Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity","year":2025,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Women and Children's Health Research Institute; Heart and Stroke Foundation of Canada","keywords":"Cardiotoxicity; Proteolysis; Doxorubicin; Matrix metalloproteinase inhibitor; Matrix metalloproteinase; Metalloproteinase; Matrix metalloproteinase 9; Chemistry; Pharmacology; Biology; Biochemistry; Medicine; Internal medicine; Enzyme; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479393,0.0004303263,0.0003930689,0.0001778177,0.000111094,0.0001942752,0.0001862098,0.0002089014,0.001027671],"category_scores_gemma":[0.0001350776,0.0001116128,0.0002196755,0.00009057167,0.0001790097,0.0001712977,0.0001157686,0.0005621596,0.0002182508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001459738,"about_ca_system_score_gemma":0.0002406326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518938,"about_ca_topic_score_gemma":0.0005673479,"domain_scores_codex":[0.9999248,0.00001247094,0.000008874683,0.0000121993,0.00001159923,0.00003019901],"domain_scores_gemma":[0.9998653,0.00001426079,0.00005402516,0.00001105763,0.00001131612,0.00004409001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001017572,0.000173177,0.0003323124,0.00007337918,0.00001452737,0.00005522179,0.00001183127,0.000057185,0.995836,0.0000343487,0.00007770369,0.00231661],"study_design_scores_gemma":[0.0002797097,0.004900987,0.01137479,0.00002718795,0.00007437662,0.0003403802,0.00003956442,0.0008322656,0.9804962,0.00004449531,0.001582391,0.000007703017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965798,0.001898605,0.0006851387,0.0000657519,0.00004256321,0.00003266211,0.0001353346,0.00005740339,0.0005027634],"genre_scores_gemma":[0.9960921,0.001522954,0.0007665904,0.00004092486,0.00002082966,0.00005149013,0.0003538232,0.00001147231,0.001139784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027671,"threshold_uncertainty_score":0.003437936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008974569787960377,"score_gpt":0.2935512122242327,"score_spread":0.2845766424362723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}