{"id":"W4410455350","doi":"10.1038/s41541-025-01151-8","title":"Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy","year":2025,"lang":"en","type":"article","venue":"npj Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Sanofi Genzyme; National Institutes of Health; TG Therapeutics; National Institute of General Medical Sciences; University of Pennsylvania; Novo Nordisk; National Multiple Sclerosis Society; Horizon Therapeutics; Genentech; Novartis Pharmaceuticals Corporation; Multiple Sclerosis Society; Atara Biotherapeutics; Biogen; Celgene; EMD Serono; Alexion Pharmaceuticals; Eli Lilly and Company; U.S. Department of Defense; Sanofi; GlaxoSmithKline; Multiple Sclerosis Society of Canada; Amgen","keywords":"Coronavirus disease 2019 (COVID-19); Immunity; Virology; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Immunology; Cell therapy; Cell mediated immunity; Cell; Biology; Immune system; Outbreak; Internal medicine; Disease; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003136526,0.0001987436,0.0005663289,0.0003267079,0.0004291686,0.0003920723,0.0001231953,0.0003729584,0.001171992],"category_scores_gemma":[0.000568373,0.0001011787,0.0001754884,0.000235502,0.0002107582,0.0002752573,0.0002116449,0.0004732975,0.0003128734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809742,"about_ca_system_score_gemma":0.000278763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006272385,"about_ca_topic_score_gemma":0.0006638027,"domain_scores_codex":[0.9998367,0.00003593039,0.00001972125,0.00003326953,0.00002548908,0.00004891988],"domain_scores_gemma":[0.9997408,0.00005061334,0.00005183945,0.00001807758,0.00004357782,0.00009507313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03253019,0.004993038,0.4181609,0.0003163427,0.0001968134,0.004104097,0.001216009,0.0006014881,0.3429339,0.0002859505,0.001846772,0.1928144],"study_design_scores_gemma":[0.001318117,0.06175561,0.8748272,0.0001138576,0.0003582003,0.008134075,0.0006558154,0.001613827,0.04037085,0.0003496284,0.01046518,0.00003755035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985058,0.0003626337,0.00009527353,0.00006061582,0.000009201503,0.00002979687,0.00005294766,0.000009075709,0.0008747031],"genre_scores_gemma":[0.9991574,0.0001236715,0.00008810353,0.00008945657,0.00001111234,0.00001875307,0.000130985,0.000002058862,0.0003785685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171992,"threshold_uncertainty_score":0.003920734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067035906283471,"score_gpt":0.3435058486765491,"score_spread":0.3128354896137144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}