{"id":"W4410457425","doi":"10.1101/2025.05.13.653835","title":"Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Refractory (planetary science); Phosphodiesterase; Epilepsy; Pharmacology; Medicine; Neuroscience; Psychology; Chemistry; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550993,0.0003662212,0.0003133036,0.0002533711,0.0000936228,0.0002802871,0.0002548287,0.0002425649,0.001732728],"category_scores_gemma":[0.0000616803,0.0001060435,0.0003360278,0.0001409258,0.0001864135,0.0001745934,0.0001925054,0.0007594932,0.0003788972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235305,"about_ca_system_score_gemma":0.0002438593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006002073,"about_ca_topic_score_gemma":0.00222051,"domain_scores_codex":[0.9999613,0.000006763826,0.000003071435,0.000008477657,0.00001049378,0.000009856788],"domain_scores_gemma":[0.9999814,0.000002326761,0.000006039193,0.000001556725,0.000003107439,0.000005538002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006811496,0.0002650259,0.0004383989,0.0006240467,0.00009128772,0.0002602684,0.0000281831,0.001280555,0.9229144,0.001744437,0.00195514,0.06971705],"study_design_scores_gemma":[0.001345037,0.007348327,0.007711879,0.0002701021,0.0004502299,0.002315915,0.0001016327,0.01422159,0.8506173,0.001849806,0.1136842,0.00008390635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8274024,0.1045539,0.04078197,0.003565788,0.0007344387,0.0005549835,0.002021026,0.001043128,0.01934219],"genre_scores_gemma":[0.9516297,0.02940255,0.01028901,0.0008451567,0.00008803586,0.000116822,0.0009848829,0.00003277503,0.006611161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732728,"threshold_uncertainty_score":0.005796611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227556685797889,"score_gpt":0.2598677837777337,"score_spread":0.2375922169197548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}