{"id":"W4410459497","doi":"10.1016/j.hrthm.2025.05.023","title":"Polygenic risk scores in arrhythmia prediction: Toward integrative models","year":2025,"lang":"en","type":"editorial","venue":"Heart Rhythm","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canada Research Chairs","keywords":"Medicine; Polygenic risk score; Internal medicine; Cardiology; Single-nucleotide polymorphism; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004615104,0.0004731474,0.001118549,0.000651297,0.0001012027,0.00006000783,0.00008548484,0.0008460883,0.0001763158],"category_scores_gemma":[0.001140039,0.0003986184,0.0004573143,0.0005823616,0.00008036986,0.0002050447,0.0001450339,0.001312986,0.000116377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003690354,"about_ca_system_score_gemma":0.0007580494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000425821,"about_ca_topic_score_gemma":0.0001519018,"domain_scores_codex":[0.9971111,0.0001652839,0.000780947,0.0006839604,0.0008477786,0.0004109484],"domain_scores_gemma":[0.9981679,0.0006738452,0.0002213675,0.0005410202,0.0002626916,0.0001332098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005161948,0.000006708851,0.002605801,0.0002732138,0.0001973602,0.00007228454,0.0003249256,0.0002093053,0.000001307063,0.0003454095,0.9936243,0.001823213],"study_design_scores_gemma":[0.002082127,0.0001919933,0.002463012,0.001034493,0.0003387494,0.00002188136,0.0001278615,0.002124691,0.00001366643,0.001448486,0.9898573,0.0002957113],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.001407942,0.003453279,0.001504771,0.004556319,0.9780024,0.001993226,0.000517465,0.0003628414,0.008201787],"genre_scores_gemma":[0.007277802,0.002751212,0.0009241189,0.0001219941,0.9503021,0.00004340501,0.0008675831,0.00006137964,0.03765045],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02944867,"threshold_uncertainty_score":0.9998466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03333017669478049,"score_gpt":0.3259150701752327,"score_spread":0.2925848934804522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}