{"id":"W4410468792","doi":"10.1038/s41437-025-00769-7","title":"CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans","year":2025,"lang":"en","type":"article","venue":"Heredity","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"CIHR Skin Research Training Centre; Government of Canada","keywords":"Biology; Metabolism; Evolutionary biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002552254,0.0001281193,0.0001997015,0.00002198617,0.00008026038,0.00001635997,0.0001837363,0.0001512913,0.00004719386],"category_scores_gemma":[0.0001495606,0.0001029367,0.00005054707,0.00009108773,0.0002054703,0.000003208138,0.0002219725,0.00009933433,0.000002527886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009860572,"about_ca_system_score_gemma":0.00005970469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000188596,"about_ca_topic_score_gemma":0.000947746,"domain_scores_codex":[0.9991765,0.00008226976,0.000205249,0.0002582015,0.00009368223,0.0001840941],"domain_scores_gemma":[0.999406,0.00004177594,0.00006322621,0.0003799175,0.0000602201,0.00004890842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001449079,0.00016959,0.05758178,0.0001656509,0.0001560746,0.000004010584,0.001189259,0.0008072687,0.9269627,0.0003941052,0.01101159,0.001413036],"study_design_scores_gemma":[0.0009835451,0.00003704957,0.436778,0.00002339076,0.00006125539,0.000003643814,0.0001995506,0.0002223361,0.4998145,0.0006178606,0.06105883,0.000200107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946773,0.003566482,0.0001366563,0.0006086796,0.0002648988,0.0001942997,0.00003299336,0.000007192682,0.0005114639],"genre_scores_gemma":[0.9973226,0.0005249909,0.0001349602,0.0004201987,0.00009930533,0.000009605768,0.00001876868,0.00001046026,0.001459139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4271483,"threshold_uncertainty_score":0.4197638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007001411800184934,"score_gpt":0.2300568172056821,"score_spread":0.2230554054054972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}