{"id":"W4410477757","doi":"10.3389/fcell.2025.1608976","title":"Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Placentation; Trophoblast; Nodal signaling; Decidua; Biology; NODAL; Blastocyst; Placenta; Andrology; Immunostaining; Embryo; Cell biology; Embryogenesis; Internal medicine; Fetus; Immunology; Pregnancy; Anatomy; Genetics; Immunohistochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004456808,0.0007351962,0.0004779589,0.001663073,0.0004818421,0.0008791094,0.0008415174,0.001158837,0.004841626],"category_scores_gemma":[0.0002682375,0.0007122637,0.0006029983,0.000547147,0.0008541242,0.000778172,0.000676781,0.001869937,0.001560514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007450184,"about_ca_system_score_gemma":0.0004578201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009001782,"about_ca_topic_score_gemma":0.001394481,"domain_scores_codex":[0.9991923,0.00007228787,0.0000844657,0.0002588521,0.000226085,0.0001660677],"domain_scores_gemma":[0.9996196,0.00003620223,0.0001386803,0.00003850702,0.00002449374,0.0001423584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003656476,0.00003199901,0.0004993893,0.0001114423,0.000008590678,0.0001543793,0.00007828995,0.0001036052,0.9955318,0.0007963938,0.0001222659,0.002196172],"study_design_scores_gemma":[0.0001201431,0.0003685152,0.01346702,0.00008817768,0.00009271732,0.001840205,0.0001946429,0.001628451,0.9610546,0.0004125723,0.02070508,0.00002788241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9295186,0.02180343,0.02958881,0.0006886746,0.0002077822,0.0002537228,0.005509678,0.001156448,0.01127291],"genre_scores_gemma":[0.9329848,0.007639566,0.02049423,0.0003283079,0.00004338297,0.0007657162,0.003884638,0.0005795555,0.03327985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004841626,"threshold_uncertainty_score":0.01619685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007758611729043863,"score_gpt":0.2041981661692266,"score_spread":0.1964395544401827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}