{"id":"W4410479057","doi":"10.1007/s12010-025-05235-y","title":"Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies","year":2025,"lang":"en","type":"article","venue":"Applied Biochemistry and Biotechnology","topic":"Electrochemical sensors and biosensors","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Trametes versicolor; Laccase; Detoxification (alternative medicine); Indole test; Chemistry; Biocompatible material; Indole-3-acetic acid; Synchrotron; Biochemistry; In situ; Nanotechnology; Nuclear chemistry; Organic chemistry; Enzyme; Materials science; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007995731,0.0001664098,0.0001959445,0.00009666923,0.00008240807,0.00002102056,0.00007274794,0.0002062662,0.000001138117],"category_scores_gemma":[0.00002379094,0.0001383491,0.00001454339,0.0002543519,0.0005208941,0.0000236507,0.00005633917,0.0002212162,2.141345e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007306771,"about_ca_system_score_gemma":0.00001588515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004752046,"about_ca_topic_score_gemma":0.000001784484,"domain_scores_codex":[0.9992868,0.00001150223,0.0002091466,0.0002603261,0.00006930748,0.0001628919],"domain_scores_gemma":[0.9997319,0.0000629306,0.00006111472,0.0001007675,0.00001905941,0.00002425754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003076515,0.00002468001,0.0001798836,0.0001489812,0.00003535721,6.855059e-7,0.0001343897,0.00003164784,0.9974099,0.001161348,0.00001750925,0.0008248203],"study_design_scores_gemma":[0.000438134,0.00003806006,0.0001539561,0.0001203661,0.00001533872,0.000007111965,0.000658489,0.00297613,0.9941989,0.001251961,0.00001126813,0.0001303032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963278,0.002293326,0.00003855622,0.0008778505,0.00001058943,0.0003576255,0.000005599378,0.00005310767,0.00003557491],"genre_scores_gemma":[0.9992241,0.0001029669,0.0005333661,0.00007855431,0.000008721238,0.00003170695,0.000009581196,0.000007465647,0.000003500591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211051,"threshold_uncertainty_score":0.5641714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589329349995956,"score_gpt":0.2332583887442888,"score_spread":0.2173650952443293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}