{"id":"W4410479057","doi":"10.1007/s12010-025-05235-y","title":"Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies","year":2025,"lang":"en","type":"article","venue":"Applied Biochemistry and Biotechnology","topic":"Electrochemical sensors and biosensors","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Trametes versicolor; Laccase; Detoxification (alternative medicine); Indole test; Chemistry; Biocompatible material; Indole-3-acetic acid; Synchrotron; Biochemistry; In situ; Nanotechnology; Nuclear chemistry; Organic chemistry; Enzyme; Materials science; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205789,0.0001790456,0.0001777301,0.0000687956,0.0001340555,0.0001906873,0.0003136096,0.0002529906,0.0003408946],"category_scores_gemma":[0.0001080157,0.00007684273,0.000191897,0.0001412913,0.0001683905,0.0002081624,0.0000996097,0.0002112016,0.00006626071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975239,"about_ca_system_score_gemma":0.0001208289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001686295,"about_ca_topic_score_gemma":0.001424012,"domain_scores_codex":[0.9999577,0.000005433157,0.000001708234,0.000009288971,0.00001689982,0.000008985261],"domain_scores_gemma":[0.9999563,0.00001008182,0.00001169287,0.000004337025,0.0000130952,0.000004523326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006201947,0.00003458451,0.0007719159,0.00005492557,0.000008210695,0.00006191889,0.0000286031,0.001279582,0.9954315,0.000158482,0.00003733985,0.00207089],"study_design_scores_gemma":[0.00000493634,0.0001227376,0.003466781,0.000001719416,0.00001039666,0.00006620611,0.0000731241,0.0170652,0.9786432,0.00003663872,0.0005047801,0.000004263036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982399,0.0002306601,0.001186394,0.00003198984,0.000002095686,0.000002497067,0.00003024214,0.00001281353,0.0002633678],"genre_scores_gemma":[0.9979526,0.0002987478,0.0012587,0.000007646193,0.000001290425,0.000002703204,0.00006222305,0.000002900815,0.0004131645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001686295,"threshold_uncertainty_score":0.00335294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589329349995956,"score_gpt":0.2332583887442888,"score_spread":0.2173650952443293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}