{"id":"W4410479347","doi":"10.1021/acs.est.4c10887","title":"Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A","year":2025,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Environment and Climate Change Canada","funders":"Environment and Climate Change Canada","keywords":"Adverse Outcome Pathway; Ethinylestradiol; Bisphenol A; Embryo; Estrogen; Agonism; Adverse effect; Estrogen receptor; Chemistry; Internal medicine; Pharmacology; Endocrinology; Biology; Andrology; Cell biology; Medicine; Environmental health; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007966313,0.000229723,0.000117406,0.0002365069,0.000158284,0.000167499,0.00008231587,0.0002182733,0.001121921],"category_scores_gemma":[0.00007843991,0.0001613768,0.0002488099,0.00009788485,0.0001949813,0.0001006904,0.0001474381,0.0002688671,0.0002059449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282517,"about_ca_system_score_gemma":0.0001454117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002256087,"about_ca_topic_score_gemma":0.00633224,"domain_scores_codex":[0.9999002,0.00001191791,0.00001256475,0.00003051652,0.00002734839,0.00001748122],"domain_scores_gemma":[0.9998809,0.00002514888,0.00004180264,0.00001299036,0.00002164114,0.00001742384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006396947,0.000005877275,0.0007623579,0.0000371259,0.000004271744,0.0001037455,0.00002167253,0.00002698173,0.9984668,0.00002909341,0.00002860597,0.0004496175],"study_design_scores_gemma":[0.00001143589,0.0005385685,0.08537319,0.0000150108,0.00003753728,0.001042143,0.0002379435,0.0005005424,0.9082366,0.00004934305,0.00394667,0.00001106377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905983,0.001306309,0.003256517,0.0001302186,0.00003130371,0.00005280882,0.001663951,0.00005447331,0.002906194],"genre_scores_gemma":[0.9904346,0.001102442,0.003026947,0.0001265809,0.000005861913,0.00005006943,0.001745724,0.00001804032,0.003489704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002256087,"threshold_uncertainty_score":0.004485905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280250803731619,"score_gpt":0.327726602193244,"score_spread":0.3049240941559277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}