{"id":"W4410479686","doi":"10.1111/cas.70097","title":"Clonal Hematopoiesis and Solid Cancers","year":2025,"lang":"en","type":"review","venue":"Cancer Science","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; Leukemia and Lymphoma Society of Canada; Moonshot Research and Development Program; Leukemia and Lymphoma Society","keywords":"Haematopoiesis; Somatic evolution in cancer; Biology; Somatic cell; Carcinogenesis; Germline mutation; Cancer; Germline; Cancer research; Immunology; Stem cell; Mutation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005513437,0.0002949525,0.001305422,0.0005380963,0.0002444876,0.00008375113,0.0006007644,0.0001605829,0.0001753871],"category_scores_gemma":[0.0003562522,0.0002180929,0.0001595361,0.002170143,0.001464277,0.0001305447,0.0004468424,0.0005566605,0.00002642902],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003239622,"about_ca_system_score_gemma":0.03142549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002762501,"about_ca_topic_score_gemma":0.00002857373,"domain_scores_codex":[0.9975073,0.00003299453,0.000331954,0.0008208873,0.0007000729,0.000606756],"domain_scores_gemma":[0.9985534,0.0001701583,0.0001250505,0.0005580356,0.000221744,0.0003716441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006226844,0.000005720479,0.00001082094,0.023519,0.00004987143,0.00003973088,0.00004336347,3.118373e-7,0.000007515116,0.0002589102,0.007093473,0.9689651],"study_design_scores_gemma":[0.0001934491,0.0000347338,0.00001731605,0.02391638,0.0003437484,0.0001232132,0.00001810367,0.00004063879,0.00003908047,0.00001929442,0.975048,0.0002060242],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001568474,0.9922783,0.00002315373,0.0003444956,0.0004108475,0.000720445,0.00005437126,0.00004078445,0.006111921],"genre_scores_gemma":[0.00001219414,0.9924099,0.000360698,0.000368002,0.0002268307,0.0003243141,0.000006500666,0.00001989963,0.006271684],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9687591,"threshold_uncertainty_score":0.9740654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05538512062537605,"score_gpt":0.4524089969687432,"score_spread":0.3970238763433672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}