{"id":"W4410479958","doi":"10.1038/s41564-025-02017-4","title":"The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound","year":2025,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Malaria Research and Control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"H2020 European Research Council; Francis Crick Institute; Wellcome Trust","keywords":"Biology; Plasmodium falciparum; Kinase; Effector; Plasmodium (life cycle); Cell biology; Phosphorylation; Genetics; Computational biology; Malaria; Parasite hosting; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002722619,0.000174077,0.0004048473,0.0001447626,0.0001607632,0.00002344662,0.0002567609,0.0005161754,0.0000405963],"category_scores_gemma":[0.0004645696,0.0001158962,0.0001150867,0.0003167411,0.0003219397,0.00001884784,0.0001336224,0.001025435,0.000004489691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070966,"about_ca_system_score_gemma":0.0002671474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001575514,"about_ca_topic_score_gemma":0.0004084606,"domain_scores_codex":[0.9986603,0.0001594971,0.0002928116,0.0002959543,0.0000888361,0.000502644],"domain_scores_gemma":[0.9987516,0.0004362455,0.00008948666,0.0003575247,0.0002789315,0.0000861633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005875438,0.0001262954,0.0003809251,0.00004581891,0.0001530493,0.00001861365,0.00004883079,4.448445e-7,0.8561599,0.0009260925,0.1405412,0.001011325],"study_design_scores_gemma":[0.006796616,0.0009220073,0.0027497,0.0002050128,0.0001466226,0.0000872658,0.0004591304,0.0001729721,0.4061349,0.000226648,0.5818576,0.0002414657],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8906988,0.02247816,0.0002172026,0.07431924,0.0007845958,0.001275166,0.0006758536,0.00008368613,0.009467284],"genre_scores_gemma":[0.9913034,0.0000424452,0.00009396745,0.004008785,0.00005281994,0.00002258812,0.0003086246,0.00001233214,0.004155019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.450025,"threshold_uncertainty_score":0.4726111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008097008587617315,"score_gpt":0.2630020353102699,"score_spread":0.2549050267226526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}