{"id":"W4410484077","doi":"10.1093/molehr/gaaf018","title":"Mosaicism is more than meets the eye: transcriptional consequences of blastocyst mosaicism","year":2025,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; CReATe Fertility Centre","funders":"","keywords":"Biology; Blastocyst; Aneuploidy; Embryo; Transcriptome; Genetics; Zygote; Gene; Ploidy; Andrology; Gene expression; Embryogenesis; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097562,0.0001490012,0.0002290952,0.0001135466,0.000172343,0.00001823065,0.0001393212,0.00009449366,0.00004344765],"category_scores_gemma":[0.0002694541,0.0001140326,0.0001469469,0.0002863806,0.0004313473,0.00004165119,0.00003528065,0.0002109949,0.000006239492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004059945,"about_ca_system_score_gemma":0.00008246867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002980169,"about_ca_topic_score_gemma":0.000007825455,"domain_scores_codex":[0.9986163,0.00006626498,0.0003156269,0.0004570856,0.0003732196,0.0001714476],"domain_scores_gemma":[0.998947,0.00002856934,0.0001013206,0.0006949426,0.0001800621,0.00004805155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001696875,0.0002039116,0.003107115,0.0001443846,0.0002327516,0.0000442043,0.0006178968,0.0003061678,0.9634948,0.02457475,0.003721482,0.00338289],"study_design_scores_gemma":[0.001081313,0.0002537685,0.06379323,0.0003814217,0.0004030001,0.0000808909,0.0003221015,0.0001314087,0.9123764,0.006230665,0.01475673,0.0001890651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683701,0.002796912,0.002664214,0.02202767,0.0003295618,0.0005382132,0.00002418652,0.00009166803,0.003157511],"genre_scores_gemma":[0.9958944,0.00003172503,0.0004249223,0.0007513363,0.0001114325,0.00003505444,0.00006821482,0.00001350758,0.002669364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06068611,"threshold_uncertainty_score":0.4650114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579998766448752,"score_gpt":0.3000218193960947,"score_spread":0.2842218317316072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}